Secondary attack rate and family clustering of SARS-CoV-2 infection in children of healthcare workers with confirmed COVID-19

Shamez N  Ladhani; Nick  Andrews; Felicity  Aiano; Frances  Baawuah; Zahin  Amin-Chowdhury; Kevin E  Brown; Gayatri  Amirthalingam; Mary E  Ramsay; Thomas Waterfield; RAPID-19  Investigation team

doi:10.1093/cid/ciaa1737

Secondary attack rate and family clustering of SARS-CoV-2 infection in children of healthcare workers with confirmed COVID-19

Shamez N Ladhani, Nick Andrews, Felicity Aiano, Frances Baawuah, Zahin Amin-Chowdhury, Kevin E Brown, Gayatri Amirthalingam, Mary E Ramsay, Thomas Waterfield, RAPID-19 Investigation team

Centre for Experimental Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

We measured serum SARS-CoV-2 antibodies in 215 children of healthcare workers to estimate secondary attack rates (SAR). Twenty-one families had a parent with confirmed COVID-19. There was strong evidence of family clustering (P<0.001): 20/21 (95.2%) children were seropositive in 9 families and none of 23 children in 12 other families.

Original language	English
Journal	Clinical Infectious Diseases
Early online date	17 Nov 2020
DOIs	https://doi.org/10.1093/cid/ciaa1737
Publication status	Early online date - 17 Nov 2020

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Ladhani, Shamez N ; Andrews, Nick ; Aiano, Felicity ; Baawuah, Frances ; Amin-Chowdhury, Zahin ; Brown, Kevin E ; Amirthalingam, Gayatri ; Ramsay, Mary E ; Waterfield, Thomas ; Investigation team, RAPID-19 . / Secondary attack rate and family clustering of SARS-CoV-2 infection in children of healthcare workers with confirmed COVID-19. In: Clinical Infectious Diseases. 2020.

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title = "Secondary attack rate and family clustering of SARS-CoV-2 infection in children of healthcare workers with confirmed COVID-19",

abstract = "We measured serum SARS-CoV-2 antibodies in 215 children of healthcare workers to estimate secondary attack rates (SAR). Twenty-one families had a parent with confirmed COVID-19. There was strong evidence of family clustering (P<0.001): 20/21 (95.2%) children were seropositive in 9 families and none of 23 children in 12 other families.",

author = "Ladhani, {Shamez N} and Nick Andrews and Felicity Aiano and Frances Baawuah and Zahin Amin-Chowdhury and Brown, {Kevin E} and Gayatri Amirthalingam and Ramsay, {Mary E} and Thomas Waterfield and {Investigation team}, RAPID-19",

year = "2020",

month = nov,

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doi = "10.1093/cid/ciaa1737",

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journal = "Clinical Infectious Diseases",

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Secondary attack rate and family clustering of SARS-CoV-2 infection in children of healthcare workers with confirmed COVID-19. / Ladhani, Shamez N ; Andrews, Nick ; Aiano, Felicity ; Baawuah, Frances ; Amin-Chowdhury, Zahin ; Brown, Kevin E ; Amirthalingam, Gayatri ; Ramsay, Mary E ; Waterfield, Thomas; Investigation team, RAPID-19 .

In: Clinical Infectious Diseases, 17.11.2020.

Research output: Contribution to journal › Article › peer-review

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AU - Ladhani, Shamez N

AU - Andrews, Nick

AU - Aiano, Felicity

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AU - Amin-Chowdhury, Zahin

AU - Brown, Kevin E

AU - Amirthalingam, Gayatri

AU - Ramsay, Mary E

AU - Waterfield, Thomas

AU - Investigation team, RAPID-19

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AB - We measured serum SARS-CoV-2 antibodies in 215 children of healthcare workers to estimate secondary attack rates (SAR). Twenty-one families had a parent with confirmed COVID-19. There was strong evidence of family clustering (P<0.001): 20/21 (95.2%) children were seropositive in 9 families and none of 23 children in 12 other families.

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DO - 10.1093/cid/ciaa1737

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