Secondary attack rate and family clustering of SARS-CoV-2 infection in children of healthcare workers with confirmed COVID-19

Shamez N  Ladhani; Nick  Andrews; Felicity  Aiano; Frances  Baawuah; Zahin  Amin-Chowdhury; Kevin E  Brown; Gayatri  Amirthalingam; Mary E  Ramsay; Thomas Waterfield; RAPID-19  Investigation team

doi:10.1093/cid/ciaa1737

Secondary attack rate and family clustering of SARS-CoV-2 infection in children of healthcare workers with confirmed COVID-19

Shamez N Ladhani, Nick Andrews, Felicity Aiano, Frances Baawuah, Zahin Amin-Chowdhury, Kevin E Brown, Gayatri Amirthalingam, Mary E Ramsay, Thomas Waterfield, RAPID-19 Investigation team

Wellcome Wolfson Institute for Experimental Medicine

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Abstract

We measured serum SARS-CoV-2 antibodies in 215 children of healthcare workers to estimate secondary attack rates (SAR). Twenty-one families had a parent with confirmed COVID-19. There was strong evidence of family clustering (P<0.001): 20/21 (95.2%) children were seropositive in 9 families and none of 23 children in 12 other families.

Original language	English
Journal	Clinical Infectious Diseases
Early online date	17 Nov 2020
DOIs	https://doi.org/10.1093/cid/ciaa1737
Publication status	Early online date - 17 Nov 2020

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10.1093/cid/ciaa1737Licence: Unspecified

Secondary attack rate and family clustering of SARS-CoV-2 infection in children of healthcare workers with confirmed COVID-19
© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. This work is made available online in accordance with the publisher’s policies. Please refer to any applicable terms of use of the publisher.
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Ladhani, Shamez N ; Andrews, Nick ; Aiano, Felicity ; Baawuah, Frances ; Amin-Chowdhury, Zahin ; Brown, Kevin E ; Amirthalingam, Gayatri ; Ramsay, Mary E ; Waterfield, Thomas ; Investigation team, RAPID-19 . / Secondary attack rate and family clustering of SARS-CoV-2 infection in children of healthcare workers with confirmed COVID-19. In: Clinical Infectious Diseases. 2020.

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title = "Secondary attack rate and family clustering of SARS-CoV-2 infection in children of healthcare workers with confirmed COVID-19",

abstract = "We measured serum SARS-CoV-2 antibodies in 215 children of healthcare workers to estimate secondary attack rates (SAR). Twenty-one families had a parent with confirmed COVID-19. There was strong evidence of family clustering (P<0.001): 20/21 (95.2%) children were seropositive in 9 families and none of 23 children in 12 other families.",

author = "Ladhani, {Shamez N} and Nick Andrews and Felicity Aiano and Frances Baawuah and Zahin Amin-Chowdhury and Brown, {Kevin E} and Gayatri Amirthalingam and Ramsay, {Mary E} and Thomas Waterfield and {Investigation team}, RAPID-19",

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Secondary attack rate and family clustering of SARS-CoV-2 infection in children of healthcare workers with confirmed COVID-19. / Ladhani, Shamez N ; Andrews, Nick ; Aiano, Felicity ; Baawuah, Frances ; Amin-Chowdhury, Zahin ; Brown, Kevin E ; Amirthalingam, Gayatri ; Ramsay, Mary E ; Waterfield, Thomas; Investigation team, RAPID-19 .

In: Clinical Infectious Diseases, 17.11.2020.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Secondary attack rate and family clustering of SARS-CoV-2 infection in children of healthcare workers with confirmed COVID-19

AU - Ladhani, Shamez N

AU - Andrews, Nick

AU - Aiano, Felicity

AU - Baawuah, Frances

AU - Amin-Chowdhury, Zahin

AU - Brown, Kevin E

AU - Amirthalingam, Gayatri

AU - Ramsay, Mary E

AU - Waterfield, Thomas

AU - Investigation team, RAPID-19

PY - 2020/11/17

Y1 - 2020/11/17

N2 - We measured serum SARS-CoV-2 antibodies in 215 children of healthcare workers to estimate secondary attack rates (SAR). Twenty-one families had a parent with confirmed COVID-19. There was strong evidence of family clustering (P<0.001): 20/21 (95.2%) children were seropositive in 9 families and none of 23 children in 12 other families.

AB - We measured serum SARS-CoV-2 antibodies in 215 children of healthcare workers to estimate secondary attack rates (SAR). Twenty-one families had a parent with confirmed COVID-19. There was strong evidence of family clustering (P<0.001): 20/21 (95.2%) children were seropositive in 9 families and none of 23 children in 12 other families.

U2 - 10.1093/cid/ciaa1737

DO - 10.1093/cid/ciaa1737

M3 - Article

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

ER -

Secondary attack rate and family clustering of SARS-CoV-2 infection in children of healthcare workers with confirmed COVID-19

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