Secretory leucoprotease inhibitor prevents lipopolysaccharide-induced Ikappa Balpha degradation without affecting phosphorylation or ubiquitination

C.M. Greene, N.G. McElvaney, S. O'Neill, Clifford Taggart

Research output: Contribution to journalArticlepeer-review

120 Citations (Scopus)

Abstract

We demonstrate that SLPI can inhibit lipopolysaccharide-induced NF-kappaB activation in monocytes by preventing degradation of the key regulatory protein IkappaBalpha which is inefficiently degraded by the ubiquitin-proteasome pathway due to a direct effect of SLPI on the activity of this pathway. I designed this project and carried out all of the experiments.
Original languageEnglish
Pages (from-to)33648-33653
Number of pages6
JournalJournal of Biological Chemistry
Volume277(37)
Issue number37
DOIs
Publication statusPublished - 13 Sep 2002

ASJC Scopus subject areas

  • Biochemistry

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