Selective Imaging of Damaged Bone Structure (Microcracks) Using a Targeting Supramolecular Eu(III) Complex As a Lanthanide Luminescent Contrast Agent

Brian McMahon, Peter Mauer, Colin P. McCoy, T. Clive Lee, Thorfinnur Gunnlaugsson

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Abstract

The synthesis and photophysical evaluation of a new supramolecular lanthanide complex is described which was developed as a luminescent contrast agent for bone structure analysis. We show that the Eu(III) emission of this complex is not pH dependent within the physiological pH range, and that its steady state emission is not significantly modulated by a series of group I and II as well as d-metal ions, and that this agent can be successfully employed to image mechanically formed cracks (scratches) in bone samples after 4 or 24 hours, using confocal laser-scanning microscopy.
Original languageEnglish
Pages (from-to)17542-17543
Number of pages2
JournalJournal of the American Chemical Society
Volume131
Issue number48
Early online date13 Nov 2009
DOIs
Publication statusPublished - 09 Dec 2009

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