Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription

M.P. Coghlan, A.A. Culbert, D.A.E. Cross, S.L. Corcoran, J.W. Yates, N.J. Pearce, O.L. Rausch, G.J. Murphy, P.S. Carter, L.R. Cox, D. Mills, M.J. Brown, David Haigh, R.W. Ward, D.G. Smith, K.J. Murray, A.D. Reith, J.C. Holder

Research output: Contribution to journalArticlepeer-review

757 Citations (Scopus)

Abstract

Background: Glycogen synthase kinase-3 (GSK-8) is a serine/threonine protein kinase, the activity of which is inhibited by a variety of extracellular stimuli including insulin, growth factors, cell specification factors and cell adhesion. Consequently, inhibition of GSK-3 activity has been proposed to play a role in the regulation of numerous signalling pathways that elicit pleiotropic cellular responses. This report describes the identification and characterisation of potent and selective small molecule inhibitors of GSK-3.
Original languageEnglish
Pages (from-to)793-803
Number of pages11
JournalChemistry & Biology
Volume7
Issue number10
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Organic Chemistry

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