Selective solid-phase extraction sorbent for caffeine made by molecular imprinting

Georgios Theodoridis, Panagiotis Manesiotis

Research output: Contribution to journalArticlepeer-review

145 Citations (Scopus)


A molecularly imprinted polymer (MIP) was prepared with caffeine as the template molecule. Thermal polymerisation (60°C) was optimised, varying ratios of monomer, cross linker and template. The polymer was used as a solid-phase extraction (SPE) sorbent, for selective trapping and pre-concentration of caffeine. Caffeine was loaded on the MIP-SPE cartridge using different loading conditions (solvents, pH value). Washing and elution of the caffeine bound to the MIP was studied utilising different protocols. The extraction protocol was successfully applied to the direct extraction of caffeine from beverages and spiked human plasma.
Original languageEnglish
Pages (from-to)163-169
Number of pages7
JournalJournal of Chromatography A
Issue number1-2
Early online date20 Nov 2001
Publication statusPublished - 01 Mar 2002

ASJC Scopus subject areas

  • Analytical Chemistry


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