Selectivity in small molecule binding to human telomeric RNA and DNA quadruplexes

G. Collie; A.P. Reszka; Shozeb Haider; V. Gabelica; G.N. Parkinson; S. Neidle

doi:10.1039/b901889a

Selectivity in small molecule binding to human telomeric RNA and DNA quadruplexes

G. Collie, A.P. Reszka, Shozeb Haider, V. Gabelica, G.N. Parkinson, S. Neidle

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Abstract

Quadruplex RNAs are less well understood than their DNA counterparts, yet of potentially high biological relevance. The interactions of several quadruplex-binding ligands with telomeric RNA quadruplexes are reported and compared with their binding to the analogous DNA quadruplexes.

Original language	English
Pages (from-to)	7482-7484
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	48
DOIs	https://doi.org/10.1039/b901889a
Publication status	Published - 2009

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Ceramics and Composites
Electronic, Optical and Magnetic Materials
Materials Chemistry
Metals and Alloys
Surfaces, Coatings and Films

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title = "Selectivity in small molecule binding to human telomeric RNA and DNA quadruplexes",

abstract = "Quadruplex RNAs are less well understood than their DNA counterparts, yet of potentially high biological relevance. The interactions of several quadruplex-binding ligands with telomeric RNA quadruplexes are reported and compared with their binding to the analogous DNA quadruplexes.",

author = "G. Collie and A.P. Reszka and Shozeb Haider and V. Gabelica and G.N. Parkinson and S. Neidle",

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AU - Collie, G.

AU - Reszka, A.P.

AU - Haider, Shozeb

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AU - Parkinson, G.N.

AU - Neidle, S.

PY - 2009

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AB - Quadruplex RNAs are less well understood than their DNA counterparts, yet of potentially high biological relevance. The interactions of several quadruplex-binding ligands with telomeric RNA quadruplexes are reported and compared with their binding to the analogous DNA quadruplexes.

U2 - 10.1039/b901889a

DO - 10.1039/b901889a

M3 - Article

VL - 48

SP - 7482

EP - 7484

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

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