Abstract
Novel physically crosslinked graphene oxide (GO)-gelatin nanocomposite hydrogels were obtained by self-assembly. The hydrogels with various ratios of GO to gelatin were prepared, and characterized by X-ray diffraction, Fourier transform infrared spectroscopy, Raman spectroscopy, and scanning electron microscopy. The static and dynamic rheological properties of the hydrogels were investigated, along with the underlying hydrogel formation mechanisms. The storage modulus of the hydrogels (containing 98-98.5 wt % water) reached 114.5 kPa, owing to the relatively strong physical bonding (i.e., hydrogen bonding and electrostatic forces) between GO and gelatin. Drug release tests showed that the drug release from the hydrogel was pH-dependent, with 96% of the model drug released in a neutral environment, compared to 28% released in an acidic medium. These hydrogels could have potential in pH-sensitive drug delivery.
Original language | English |
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Pages (from-to) | 356-367 |
Number of pages | 12 |
Journal | Journal of Polymer Science, Part B: Polymer Physics |
Volume | 53 |
Issue number | 5 |
Early online date | 24 Nov 2014 |
DOIs | |
Publication status | Published - 01 Mar 2015 |
Keywords
- Drug delivery
- Gelatin
- Graphene oxide
- Hydrogel
- Rheology
ASJC Scopus subject areas
- Condensed Matter Physics
- Physical and Theoretical Chemistry
- Polymers and Plastics
- Materials Chemistry