Self-Assembled Supramolecular Gels of Reverse Poloxamers and Cyclodextrins

Eneko Larrañeta, Jose Ramon Isasi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

A series of supramolecular aggregates were prepared using a poly(propylene oxide) poly(ethylene oxide) poly(propylene oxide) (PPO-PEO-PPO) block copolymer and beta- or alpha-cyclodextrins (CD). The combination of beta-CD and the copolymer yields inclusion complexes (IC) with polypseudorotaxane structures. These are formed by complexation of the PPO blocks with beta-CD molecules producing a powder precipitate with a certain crystallinity degree that can be evaluated by X-ray diffraction (XRD). In contrast, when combining alpha-CD with the block copolymer, the observed effect is an increase in the viscosity of the mixtures, yielding fluid gels. Two cooperative effects come into play: the complexation of PEO blocks with alpha-CD and the hydrophobic interactions between PPO blocks in aqueous media. These two combined interactions lead to the formation of a macromoleculaf network. The resulting fluid gels were characterized using different techniques such as differential scanning calorimetry (DSC), viscometry, and XRD measurements.

Original languageEnglish
Pages (from-to)12457-12462
Number of pages6
JournalLangmuir
Volume28
Issue number34
DOIs
Publication statusPublished - 28 Aug 2012

Keywords

  • PEO TRIBLOCK COPOLYMERS
  • THREADED ALPHA-CYCLODEXTRINS
  • INCLUSION COMPLEXES
  • BETA-CYCLODEXTRIN
  • DRUG-DELIVERY
  • HYDROGELS
  • OXIDE)
  • POLYROTAXANES
  • MICELLIZATION
  • POLYPSEUDOROTAXANES

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