Abstract
lbendazole (ABZ) is a broad-spectrum antiparasitic drug used in the treatment of human or animal infections. Although ABZ has shown a high efficacy for repeated doses in monogastric mammals, its low aqueous solubility leads to erratic bioavailability. The aim of this work was to optimize a procedure in order to obtain ABZ self-dispersible nanocrystals (SDNC) by combining high pressure homogenization (HPH) and spray-drying (SD). The material thus obtained was characterized and the variables affecting both the HPH and SD processes were studied. As expected, the homogenizing pressure and number of cycles influenced the final particle size, while the stabilizer concentration had a strong impact on SD output and redispersion of powders upon contact with water. ABZ SDNC were successfully obtained with high process yield and redispersibility. The characteristic peaks of ABZ were clearly identified in the X-ray patterns of the processed samples. A noticeable increase in the dissolution rate was observed in the aqueous environment.
Original language | English |
---|---|
Journal | Drug Development and Industrial Pharmacy |
Volume | 42 |
Issue number | 10 |
Early online date | 16 Mar 2016 |
DOIs | |
Publication status | Early online date - 16 Mar 2016 |
Fingerprint
Dive into the research topics of 'Self-dispersible nanocrystals of albendazole produced by high pressure homogenization and spray-drying'. Together they form a unique fingerprint.Press / Media
-
Production of a nanometric antiparasitic drug
Alejandro Paredes, Santiago Daniel Palma & Daniel A. Allemandi
03/11/2016 → 04/11/2016
5 Media contributions
Press/Media: Research