Semaphorin and plexin gene expression is altered in the prefrontal cortex of schizophrenia patients with and without auditory hallucinations

Javier Gilabert-Juan, Ana Rosa Sáez, Guillermo Lopez-Campos, Noelia Sebastiá-Ortega, Rocio González-Martínez, Juan Costa, Josep María Haro, Luis F Callado, J Javier Meana, Juán Nacher, Julio Sanjuán, María Dolores Moltó

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Auditory hallucinations (AH) are clinical hallmarks of schizophrenia, however little is known about molecular genetics of these symptoms. In this study, gene expression profiling of postmortem brain samples from prefrontal cortex of schizophrenic patients without AH (SNA), patients with AH (SA) and control subjects were compared. Genome-wide expression analysis was conducted using samples of three individuals of each group and the Affymetrix GeneChip Human-Gene 1.0 ST-Array. This analysis identified the Axon Guidance pathway as one of the most differentially expressed network among SNA, SA and CNT. To confirm the transcriptome results, mRNA level quantification of seventeen genes involved in this pathway was performed in a larger sample. PLXNB1, SEMA3A, SEMA4D and SEM6C were upregulated in SNA or SA patients compared to controls. PLXNA1 and SEMA3D showed down-regulation in their expression in the patient's samples, but differences remained statistically significant between the SNA patients and controls. Differences between SNA and SA were found in PLXNB1 expression which is decreased in SA patients. This study strengthens the contribution of brain plasticity in pathophysiology of schizophrenia and shows that non-hallucinatory patients present more alterations in frontal regions than patients with hallucinations concerning neural plasticity.

Original languageEnglish
Pages (from-to)850-7
JournalPsychiatry Research
Volume229
Issue number3
Early online date29 Jul 2015
DOIs
Publication statusPublished - 30 Oct 2015

Keywords

  • Adult
  • Aged
  • Aged, 80 and over
  • Axons
  • Brain
  • Cell Adhesion Molecules
  • Down-Regulation
  • Gene Expression Profiling
  • Hallucinations
  • Humans
  • Middle Aged
  • Nerve Tissue Proteins
  • Neuronal Plasticity
  • Oligonucleotide Array Sequence Analysis
  • Prefrontal Cortex
  • RNA, Messenger
  • Schizophrenia
  • Semaphorins
  • Journal Article
  • Research Support, Non-U.S. Gov't

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