Cell migration is a fundamental biological process involved in tissue formationand homeostasis. The correct polarization of motile cells is critical to ensuredirected movement and is orchestrated by many intrinsic and extrinsic factors.Of these, the subcellular distribution of mRNAs and the consequent spatialcontrol of translation are key modulators of cell polarity. mRNA transport isdependent on cis-regulatory elements within transcripts, which are recognizedby trans-acting proteins that ensure the efficient delivery of certain messages toleading cell edge of migrating cells. At their destination, translation of localizedmRNAs then participates in regional cellular responses underlying cell motility.In this review, we summarize the key findings that established mRNA targetingas a critical driver of cell migration and how the characterization of polarizedmRNAs in motile cells has been expanded from just a few species to hundredsof transcripts. We also describe the molecular control of mRNA trafficking,subsequent mechanisms of local protein synthesis and how these ultimatelyregulate cell polarity during migration.
|Number of pages||12|
|Journal||Essays in Biochemistry|
|Early online date||19 Jul 2019|
|Publication status||Published - Oct 2019|