Sequence changes in predicted promoter elements of STK11/LKB1 are unlikely to contribute to Peutz-Jeghers syndrome

N.C.M. Hearle, I. Tomlinson, W. Lim, V. Murday, E. Swarbrick, G. Lim, R. Phillips, P. Lee, J. O'Donohue, R.C. Trembath, Patrick Morrison, A. Norman, R. Taylor, S. Hodgson, A. Lucassen, R.S. Houlston

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: Germline mutations or large-scale deletions in the coding region and splice sites of STK11/LKB1 do not account for all cases of Peutz-Jeghers syndrome (PJS). It is conceivable that, on the basis of data from other diseases, inherited variation in promoter elements of STK11/LKB1 may cause PJS.
Original languageEnglish
JournalBMC Genomics
Volume6
DOIs
Publication statusPublished - 17 Mar 2005

ASJC Scopus subject areas

  • Medicine(all)

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