Sequential antimicrobial therapy: treatment of severe lower respiratory tract infections in children

F.A. Al-Eidan, James McElnay, M.G. Scott, M.P. Kearney, K.E.U. Troughton, J. Jenkins

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25 Citations (Scopus)

Abstract

Although there have been a number of studies in adults, to date there has been little research into sequential antimicrobial therapy (SAT) in paediatric populations. The present study evaluates the impact of a SAT protocol for the treatment of severe lower respiratory tract infection in paediatric patients. The study involved 89 paediatric patients (44 control and 45 SAT). The SAT patients had a shorter length of hospital stay (4.0 versus 8.3 days), shorter duration of inpatient antimicrobial therapy (4.0 versus 7.9 days) with the period of iv therapy being reduced from a mean of 5.6 to 1.7 days. The total healthcare costs were reduced by 52%. The resolution of severe lower respiratory tract infection with a short course of iv antimicrobials, followed by conversion to oral therapy yielded clinical outcomes comparable to those achieved using longer term iv therapy. SAT proved to be an important cost-minimizing tool for realizing substantial healthcare costs savings.
Original languageEnglish
Pages (from-to)709-715
Number of pages7
JournalJournal of Antimicrobial Chemotherapy
Volume44
Issue number5
Publication statusPublished - 1999

ASJC Scopus subject areas

  • Microbiology
  • Pharmacology

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    Al-Eidan, F. A., McElnay, J., Scott, M. G., Kearney, M. P., Troughton, K. E. U., & Jenkins, J. (1999). Sequential antimicrobial therapy: treatment of severe lower respiratory tract infections in children. Journal of Antimicrobial Chemotherapy, 44(5), 709-715.