Although there have been a number of studies in adults, to date there has been little research into sequential antimicrobial therapy (SAT) in paediatric populations. The present study evaluates the impact of a SAT protocol for the treatment of severe lower respiratory tract infection in paediatric patients. The study involved 89 paediatric patients (44 control and 45 SAT). The SAT patients had a shorter length of hospital stay (4.0 versus 8.3 days), shorter duration of inpatient antimicrobial therapy (4.0 versus 7.9 days) with the period of iv therapy being reduced from a mean of 5.6 to 1.7 days. The total healthcare costs were reduced by 52%. The resolution of severe lower respiratory tract infection with a short course of iv antimicrobials, followed by conversion to oral therapy yielded clinical outcomes comparable to those achieved using longer term iv therapy. SAT proved to be an important cost-minimizing tool for realizing substantial healthcare costs savings.
|Number of pages||7|
|Journal||Journal of Antimicrobial Chemotherapy|
|Publication status||Published - 1999|
ASJC Scopus subject areas
Al-Eidan, F. A., McElnay, J., Scott, M. G., Kearney, M. P., Troughton, K. E. U., & Jenkins, J. (1999). Sequential antimicrobial therapy: treatment of severe lower respiratory tract infections in children. Journal of Antimicrobial Chemotherapy, 44(5), 709-715.