Sequential extracellular matrix-focused and baited-global cluster analysis of serial transcriptomic profiles identifies candidate modulators of renal tubulointerstitial fibrosis in murine adriamycin-induced nephropathy

D.M. Sadlier, S.B. Connolly, N.E. Kieran, S. Roxburgh, Derek Brazil, L. Kairaitis, Y. Wang, D.C.H. Harris, P. Doran, H.R. Brady

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Transcriptome analysis using microarray technology represents a powerful unbiased approach for delineating pathogenic mechanisms in disease. Here molecular mechanisms of renal tubulointerstitial fibrosis (TIF) were probed by monitoring changes in the renal transcriptome in a glomerular disease-dependent model of TIF ( adriamycin nephropathy) using Affymetrix (mu74av2) microarray coupled with sequential primary biological function-focused and secondary
Original languageEnglish
Pages (from-to)29670-29680
Number of pages11
JournalJournal of Biological Chemistry
Volume279
Issue number28
DOIs
Publication statusPublished - 09 Jul 2004

ASJC Scopus subject areas

  • Biochemistry

Fingerprint Dive into the research topics of 'Sequential extracellular matrix-focused and baited-global cluster analysis of serial transcriptomic profiles identifies candidate modulators of renal tubulointerstitial fibrosis in murine adriamycin-induced nephropathy'. Together they form a unique fingerprint.

Cite this