Sequential extracellular matrix-focused and baited-global cluster analysis of serial transcriptomic profiles identifies candidate modulators of renal tubulointerstitial fibrosis in murine adriamycin-induced nephropathy

D.M. Sadlier; S.B. Connolly; N.E. Kieran; S. Roxburgh; Derek Brazil; L. Kairaitis; Y. Wang; D.C.H. Harris; P. Doran; H.R. Brady

doi:10.1074/jbc.M313408200

Sequential extracellular matrix-focused and baited-global cluster analysis of serial transcriptomic profiles identifies candidate modulators of renal tubulointerstitial fibrosis in murine adriamycin-induced nephropathy

D.M. Sadlier, S.B. Connolly, N.E. Kieran, S. Roxburgh, Derek Brazil, L. Kairaitis, Y. Wang, D.C.H. Harris, P. Doran, H.R. Brady

Research output: Contribution to journal › Article

46 Citations (Scopus)

Abstract

Transcriptome analysis using microarray technology represents a powerful unbiased approach for delineating pathogenic mechanisms in disease. Here molecular mechanisms of renal tubulointerstitial fibrosis (TIF) were probed by monitoring changes in the renal transcriptome in a glomerular disease-dependent model of TIF ( adriamycin nephropathy) using Affymetrix (mu74av2) microarray coupled with sequential primary biological function-focused and secondary

Original language	English
Pages (from-to)	29670-29680
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	279
Issue number	28
DOIs	https://doi.org/10.1074/jbc.M313408200
Publication status	Published - 09 Jul 2004

ASJC Scopus subject areas

Biochemistry

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Sadlier, D. M., Connolly, S. B., Kieran, N. E., Roxburgh, S., Brazil, D., Kairaitis, L., Wang, Y., Harris, D. C. H., Doran, P., & Brady, H. R. (2004). Sequential extracellular matrix-focused and baited-global cluster analysis of serial transcriptomic profiles identifies candidate modulators of renal tubulointerstitial fibrosis in murine adriamycin-induced nephropathy. Journal of Biological Chemistry, 279(28), 29670-29680. https://doi.org/10.1074/jbc.M313408200

Sadlier, D.M. ; Connolly, S.B. ; Kieran, N.E. ; Roxburgh, S. ; Brazil, Derek ; Kairaitis, L. ; Wang, Y. ; Harris, D.C.H. ; Doran, P. ; Brady, H.R. / Sequential extracellular matrix-focused and baited-global cluster analysis of serial transcriptomic profiles identifies candidate modulators of renal tubulointerstitial fibrosis in murine adriamycin-induced nephropathy. In: Journal of Biological Chemistry. 2004 ; Vol. 279, No. 28. pp. 29670-29680.

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abstract = "Transcriptome analysis using microarray technology represents a powerful unbiased approach for delineating pathogenic mechanisms in disease. Here molecular mechanisms of renal tubulointerstitial fibrosis (TIF) were probed by monitoring changes in the renal transcriptome in a glomerular disease-dependent model of TIF ( adriamycin nephropathy) using Affymetrix (mu74av2) microarray coupled with sequential primary biological function-focused and secondary",

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Sadlier, DM, Connolly, SB, Kieran, NE, Roxburgh, S, Brazil, D, Kairaitis, L, Wang, Y, Harris, DCH, Doran, P & Brady, HR 2004, 'Sequential extracellular matrix-focused and baited-global cluster analysis of serial transcriptomic profiles identifies candidate modulators of renal tubulointerstitial fibrosis in murine adriamycin-induced nephropathy', Journal of Biological Chemistry, vol. 279, no. 28, pp. 29670-29680. https://doi.org/10.1074/jbc.M313408200

Sequential extracellular matrix-focused and baited-global cluster analysis of serial transcriptomic profiles identifies candidate modulators of renal tubulointerstitial fibrosis in murine adriamycin-induced nephropathy. / Sadlier, D.M.; Connolly, S.B.; Kieran, N.E.; Roxburgh, S.; Brazil, Derek; Kairaitis, L.; Wang, Y.; Harris, D.C.H.; Doran, P.; Brady, H.R.

In: Journal of Biological Chemistry, Vol. 279, No. 28, 09.07.2004, p. 29670-29680.

Research output: Contribution to journal › Article

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Sadlier DM, Connolly SB, Kieran NE, Roxburgh S, Brazil D, Kairaitis L et al. Sequential extracellular matrix-focused and baited-global cluster analysis of serial transcriptomic profiles identifies candidate modulators of renal tubulointerstitial fibrosis in murine adriamycin-induced nephropathy. Journal of Biological Chemistry. 2004 Jul 9;279(28):29670-29680. https://doi.org/10.1074/jbc.M313408200