Serological correlate of protection against norovirus-induced gastroenteritis

Amanda Reeck; Owen Kavanagh; Mary K Estes; Antone R Opekun; Mark A Gilger; David Y Graham; Robert L Atmar

doi:10.1086/656364

Serological correlate of protection against norovirus-induced gastroenteritis

Amanda Reeck, Owen Kavanagh, Mary K Estes, Antone R Opekun, Mark A Gilger, David Y Graham, Robert L Atmar

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

237 Citations (Scopus)

Abstract

Norovirus infection is the leading cause of acute nonbacterial gastroenteritis. Histoblood group antigens (HBGAs) are host susceptibility determinants for Norwalk virus (NV) infection. We hypothesized that antibodies that block NV-HBGA binding are associated with protection from clinical illness following NV exposure.

Original language	English
Pages (from-to)	1212-8
Number of pages	7
Journal	The Journal of Infectious Diseases
Volume	202
Issue number	8
DOIs	https://doi.org/10.1086/656364
Publication status	Published - 15 Oct 2010

Keywords

Young Adult
Reproducibility of Results
Humans
Norwalk virus
Biological Assay
Polysaccharides
Virus Shedding
Antibodies, Blocking
Caliciviridae Infections
Adult
Middle Aged
Adolescent
Gastroenteritis

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10.1086/656364

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title = "Serological correlate of protection against norovirus-induced gastroenteritis",

abstract = "Norovirus infection is the leading cause of acute nonbacterial gastroenteritis. Histoblood group antigens (HBGAs) are host susceptibility determinants for Norwalk virus (NV) infection. We hypothesized that antibodies that block NV-HBGA binding are associated with protection from clinical illness following NV exposure.",

keywords = "Young Adult, Reproducibility of Results, Humans, Norwalk virus, Biological Assay, Polysaccharides, Virus Shedding, Antibodies, Blocking, Caliciviridae Infections, Adult, Middle Aged, Adolescent, Gastroenteritis",

author = "Amanda Reeck and Owen Kavanagh and Estes, {Mary K} and Opekun, {Antone R} and Gilger, {Mark A} and Graham, {David Y} and Atmar, {Robert L}",

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AU - Reeck, Amanda

AU - Kavanagh, Owen

AU - Estes, Mary K

AU - Opekun, Antone R

AU - Gilger, Mark A

AU - Graham, David Y

AU - Atmar, Robert L

PY - 2010/10/15

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N2 - Norovirus infection is the leading cause of acute nonbacterial gastroenteritis. Histoblood group antigens (HBGAs) are host susceptibility determinants for Norwalk virus (NV) infection. We hypothesized that antibodies that block NV-HBGA binding are associated with protection from clinical illness following NV exposure.

AB - Norovirus infection is the leading cause of acute nonbacterial gastroenteritis. Histoblood group antigens (HBGAs) are host susceptibility determinants for Norwalk virus (NV) infection. We hypothesized that antibodies that block NV-HBGA binding are associated with protection from clinical illness following NV exposure.

KW - Young Adult

KW - Reproducibility of Results

KW - Humans

KW - Norwalk virus

KW - Biological Assay

KW - Polysaccharides

KW - Virus Shedding

KW - Antibodies, Blocking

KW - Caliciviridae Infections

KW - Adult

KW - Middle Aged

KW - Adolescent

KW - Gastroenteritis

U2 - 10.1086/656364

DO - 10.1086/656364

M3 - Article

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EP - 1218

JO - The Journal of Infectious Diseases

JF - The Journal of Infectious Diseases

IS - 8

ER -

Serological correlate of protection against norovirus-induced gastroenteritis

Abstract

Keywords

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