Serological correlate of protection against norovirus-induced gastroenteritis

Amanda Reeck, Owen Kavanagh, Mary K Estes, Antone R Opekun, Mark A Gilger, David Y Graham, Robert L Atmar

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179 Citations (Scopus)

Abstract

Norovirus infection is the leading cause of acute nonbacterial gastroenteritis. Histoblood group antigens (HBGAs) are host susceptibility determinants for Norwalk virus (NV) infection. We hypothesized that antibodies that block NV-HBGA binding are associated with protection from clinical illness following NV exposure.
Original languageEnglish
Pages (from-to)1212-8
Number of pages7
JournalThe Journal of Infectious Diseases
Volume202
Issue number8
DOIs
Publication statusPublished - 15 Oct 2010

Keywords

  • Young Adult
  • Reproducibility of Results
  • Humans
  • Norwalk virus
  • Biological Assay
  • Polysaccharides
  • Virus Shedding
  • Antibodies, Blocking
  • Caliciviridae Infections
  • Adult
  • Middle Aged
  • Adolescent
  • Gastroenteritis

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  • Cite this

    Reeck, A., Kavanagh, O., Estes, M. K., Opekun, A. R., Gilger, M. A., Graham, D. Y., & Atmar, R. L. (2010). Serological correlate of protection against norovirus-induced gastroenteritis. The Journal of Infectious Diseases, 202(8), 1212-8. https://doi.org/10.1086/656364