Abstract
A new siderophore, serratiochelin D (1), was isolated from a soil-derived, non-pigmented strain of Serratia marcescens along with two previously reported siderophores, serratiochelins A and B. Siderophores were obtained after cultivating the bacterium in an iron-deficient medium, and the chemical structures were elucidated based on HPLC-UV, mass spectrometry, and extensive 1D and 2D NMR spectral analyses. The iron-chelating, growth-promoting, and cytotoxic activities were evaluated using standard methods. Serratiochelin D (1) demonstrated xenosiderophoric activity by promoting the growth of Staphylococcus aureus, Acinetobacter baumannii, and Mycobacterium tuberculosis in iron-limited media and thus has the potential to be developed into a sideromycin against pathogens in these genera and other MDR bacteria.
Original language | English |
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Pages (from-to) | 22-25 |
Number of pages | 4 |
Journal | Phytochemistry Letters |
Volume | 57 |
Early online date | 15 Jul 2023 |
DOIs | |
Publication status | Published - Oct 2023 |
Externally published | Yes |
Bibliographical note
Funding Information:This work was supported by the Africa Research Excellence Fund (AREF) , United Kingdom within the frame of the EDCTP-AREF Joint Preparatory Fellowship [Grant numbers: MRF-157-0034-F-EZE(A)/C0763 , MRF-157-0034-F-EZE(B)/C0764 ].
Funding Information:
P.M.E. acknowledges the Africa Research Excellence Fund (AREF, United Kingdom) for financing his research stay at the Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University, Düsseldorf, Germany. S.S.E. is grateful to the Alexander von Humboldt (AvH) Foundation (Germany) for granting him the Georg-Forster Fellowship for Experienced Researchers (Ref 3.4-1222288-EGY-GF-E). The authors thank the CeMSA@HHU (Center for Molecular and Structural Analytic at the Heinrich Heine University, Düsseldorf) for recording the mass spectrometric and NMR spectroscopic data.
Publisher Copyright:
© 2023 Phytochemical Society of Europe
Keywords
- Antibiotic resistance
- Serratia marcescens
- Serratiochelin
- Sideromycin
- Siderophore
ASJC Scopus subject areas
- Biotechnology
- Biochemistry
- Agronomy and Crop Science
- Plant Science