Serratiochelin D, a new siderophore from Serratia marcescens

Peter M. Eze*, Viktor E. Simons, Marian Frank, Lasse van Geelen, Chika C. Abba, Sherif S. Ebada*, Charles O. Esimone, Festus B.C. Okoye, Peter Proksch, Rainer Kalscheuer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

A new siderophore, serratiochelin D (1), was isolated from a soil-derived, non-pigmented strain of Serratia marcescens along with two previously reported siderophores, serratiochelins A and B. Siderophores were obtained after cultivating the bacterium in an iron-deficient medium, and the chemical structures were elucidated based on HPLC-UV, mass spectrometry, and extensive 1D and 2D NMR spectral analyses. The iron-chelating, growth-promoting, and cytotoxic activities were evaluated using standard methods. Serratiochelin D (1) demonstrated xenosiderophoric activity by promoting the growth of Staphylococcus aureus, Acinetobacter baumannii, and Mycobacterium tuberculosis in iron-limited media and thus has the potential to be developed into a sideromycin against pathogens in these genera and other MDR bacteria.

Original languageEnglish
Pages (from-to)22-25
Number of pages4
JournalPhytochemistry Letters
Volume57
Early online date15 Jul 2023
DOIs
Publication statusPublished - Oct 2023
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by the Africa Research Excellence Fund (AREF) , United Kingdom within the frame of the EDCTP-AREF Joint Preparatory Fellowship [Grant numbers: MRF-157-0034-F-EZE(A)/C0763 , MRF-157-0034-F-EZE(B)/C0764 ].

Funding Information:
P.M.E. acknowledges the Africa Research Excellence Fund (AREF, United Kingdom) for financing his research stay at the Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University, Düsseldorf, Germany. S.S.E. is grateful to the Alexander von Humboldt (AvH) Foundation (Germany) for granting him the Georg-Forster Fellowship for Experienced Researchers (Ref 3.4-1222288-EGY-GF-E). The authors thank the CeMSA@HHU (Center for Molecular and Structural Analytic at the Heinrich Heine University, Düsseldorf) for recording the mass spectrometric and NMR spectroscopic data.

Publisher Copyright:
© 2023 Phytochemical Society of Europe

Keywords

  • Antibiotic resistance
  • Serratia marcescens
  • Serratiochelin
  • Sideromycin
  • Siderophore

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Agronomy and Crop Science
  • Plant Science

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