Serum concentrations of vitamin E and carotenoids are altered in Alzheimer's disease: a case control study

Kathryn Mullan; Michael Williams; Christopher Cardwell; Bernadette McGuinness; Anthony Passmore; Giuliana Silvestri; Jayne Woodside; Gareth McKay

doi:10.1016/j.trci.2017.06.006

Serum concentrations of vitamin E and carotenoids are altered in Alzheimer's disease: a case control study

Kathryn Mullan, Michael Williams, Christopher Cardwell, Bernadette McGuinness, Anthony Passmore, Giuliana Silvestri, Jayne Woodside, Gareth McKay

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Abstract

IntroductionOxidative stress has been implicated in the pathogenesis of Alzheimer's disease (AD). We investigated associations between serum levels of lipophilic antioxidants and AD.
MethodsSerum concentrations of retinol, two forms of vitamin E (α- and γ-tocopherol) and six carotenoids were quantified by high-performance liquid chromatography from patients with AD (n = 251) and cognitively intact controls (n = 308) and assessed by regression analyses.
ResultsSerum levels of α-tocopherol and all six carotenoids were significantly lower in patients with AD compared with cognitively intact controls (P < .001). In contrast, γ-tocopherol was significantly higher in the serum of patients with AD (odds ratio = 1.17 [confidence intervals: 1.05–1.31]).
DiscussionOur findings implicate compromised serum antioxidant defenses in AD pathogenesis and differing biological roles for vitamin E isoforms. This highlights the need for improved understanding in the balanced upregulation of exogenous antioxidants related to dietary intake or supplement use in future nutritional intervention studies.

Original language	English
Pages (from-to)	432 -439
Journal	Alzheimer's & Dementia: Translational Research and Clinical Interventions
Volume	3
Issue number	3
Early online date	01 Sept 2017
DOIs	https://doi.org/10.1016/j.trci.2017.06.006
Publication status	Early online date - 01 Sept 2017

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Serum concentrations of vitamin E and carotenoids are altered in Alzheimer’s disease: A case-control study
Copyright 2017 Elsevier. This manuscript is distributed under a Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits distribution and reproduction for non-commercial purposes, provided the author and source are cited.
Final published version, 306 KBLicence: CC BY-NC-ND

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Mullan, K., Williams, M., Cardwell, C., McGuinness, B., Passmore, A., Silvestri, G., Woodside, J., & McKay, G. (2017). Serum concentrations of vitamin E and carotenoids are altered in Alzheimer's disease: a case control study. Alzheimer's & Dementia: Translational Research and Clinical Interventions, 3(3), 432 -439. Advance online publication. https://doi.org/10.1016/j.trci.2017.06.006

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abstract = "IntroductionOxidative stress has been implicated in the pathogenesis of Alzheimer's disease (AD). We investigated associations between serum levels of lipophilic antioxidants and AD. MethodsSerum concentrations of retinol, two forms of vitamin E (α- and γ-tocopherol) and six carotenoids were quantified by high-performance liquid chromatography from patients with AD (n = 251) and cognitively intact controls (n = 308) and assessed by regression analyses. ResultsSerum levels of α-tocopherol and all six carotenoids were significantly lower in patients with AD compared with cognitively intact controls (P < .001). In contrast, γ-tocopherol was significantly higher in the serum of patients with AD (odds ratio = 1.17 [confidence intervals: 1.05–1.31]). DiscussionOur findings implicate compromised serum antioxidant defenses in AD pathogenesis and differing biological roles for vitamin E isoforms. This highlights the need for improved understanding in the balanced upregulation of exogenous antioxidants related to dietary intake or supplement use in future nutritional intervention studies.",

author = "Kathryn Mullan and Michael Williams and Christopher Cardwell and Bernadette McGuinness and Anthony Passmore and Giuliana Silvestri and Jayne Woodside and Gareth McKay",

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T1 - Serum concentrations of vitamin E and carotenoids are altered in Alzheimer's disease: a case control study

AU - Mullan, Kathryn

AU - Williams, Michael

AU - Cardwell, Christopher

AU - McGuinness, Bernadette

AU - Passmore, Anthony

AU - Silvestri, Giuliana

AU - Woodside, Jayne

AU - McKay, Gareth

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N2 - IntroductionOxidative stress has been implicated in the pathogenesis of Alzheimer's disease (AD). We investigated associations between serum levels of lipophilic antioxidants and AD. MethodsSerum concentrations of retinol, two forms of vitamin E (α- and γ-tocopherol) and six carotenoids were quantified by high-performance liquid chromatography from patients with AD (n = 251) and cognitively intact controls (n = 308) and assessed by regression analyses. ResultsSerum levels of α-tocopherol and all six carotenoids were significantly lower in patients with AD compared with cognitively intact controls (P < .001). In contrast, γ-tocopherol was significantly higher in the serum of patients with AD (odds ratio = 1.17 [confidence intervals: 1.05–1.31]). DiscussionOur findings implicate compromised serum antioxidant defenses in AD pathogenesis and differing biological roles for vitamin E isoforms. This highlights the need for improved understanding in the balanced upregulation of exogenous antioxidants related to dietary intake or supplement use in future nutritional intervention studies.

AB - IntroductionOxidative stress has been implicated in the pathogenesis of Alzheimer's disease (AD). We investigated associations between serum levels of lipophilic antioxidants and AD. MethodsSerum concentrations of retinol, two forms of vitamin E (α- and γ-tocopherol) and six carotenoids were quantified by high-performance liquid chromatography from patients with AD (n = 251) and cognitively intact controls (n = 308) and assessed by regression analyses. ResultsSerum levels of α-tocopherol and all six carotenoids were significantly lower in patients with AD compared with cognitively intact controls (P < .001). In contrast, γ-tocopherol was significantly higher in the serum of patients with AD (odds ratio = 1.17 [confidence intervals: 1.05–1.31]). DiscussionOur findings implicate compromised serum antioxidant defenses in AD pathogenesis and differing biological roles for vitamin E isoforms. This highlights the need for improved understanding in the balanced upregulation of exogenous antioxidants related to dietary intake or supplement use in future nutritional intervention studies.

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DO - 10.1016/j.trci.2017.06.006

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JO - Alzheimer's & Dementia: Translational Research and Clinical Interventions

JF - Alzheimer's & Dementia: Translational Research and Clinical Interventions

IS - 3

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Serum concentrations of vitamin E and carotenoids are altered in Alzheimer's disease: a case control study

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