Serum erythropoietic activity in acute anemia--an animal model

M F McMullin, T R Lappin, G E Elder, T Taylor, J M Bridges

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4 Citations (Scopus)

Abstract

Serum erythropoietic activity and reticulocyte response to anemia were investigated using a rabbit model. In hemolytic anemia, induced by injections of phenylhydrazine on Day 0 the hemoglobin reached a nadir (mean, 6.23 g/dl) on Day 4 when SEA was maximal (mean, 765 mU/ml). In animals venesected on Day 0 and Day 1 to produce anemia of equal severity, the SEA was maximal (mean 235 mU/ml) on Day 2. In both groups the reticulocyte response peaked on Day 7--at 34% for the hemolytic group and 21% for the venesected group. The 2,3-diphosphoglycerate, measured on Day 4, was significantly reduced in the PHZ-treated group. In the venesected group the 2,3-DPG increased between Day 0 and Day 4. There were no concurrent changes in acid-base balance. These results imply that the degree of anemia is only one of the factors which influence the level of circulating SEA.
Original languageEnglish
Pages (from-to)30-5
Number of pages6
JournalBiochemical medicine and metabolic biology
Volume41
Issue number1
Publication statusPublished - Feb 1989

Keywords

  • Acute Disease
  • Anemia, Hemolytic
  • Animals
  • Disease Models, Animal
  • Erythropoiesis
  • Hemoglobins
  • Phenylhydrazines
  • Rabbits

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