Serum erythropoietic activity in acute anemia--an animal model

M F McMullin; T R Lappin; G E Elder; T Taylor; J M Bridges

Serum erythropoietic activity in acute anemia--an animal model

M F McMullin, T R Lappin, G E Elder, T Taylor, J M Bridges

Research output: Contribution to journal › Article › peer-review

Abstract

Serum erythropoietic activity and reticulocyte response to anemia were investigated using a rabbit model. In hemolytic anemia, induced by injections of phenylhydrazine on Day 0 the hemoglobin reached a nadir (mean, 6.23 g/dl) on Day 4 when SEA was maximal (mean, 765 mU/ml). In animals venesected on Day 0 and Day 1 to produce anemia of equal severity, the SEA was maximal (mean 235 mU/ml) on Day 2. In both groups the reticulocyte response peaked on Day 7--at 34% for the hemolytic group and 21% for the venesected group. The 2,3-diphosphoglycerate, measured on Day 4, was significantly reduced in the PHZ-treated group. In the venesected group the 2,3-DPG increased between Day 0 and Day 4. There were no concurrent changes in acid-base balance. These results imply that the degree of anemia is only one of the factors which influence the level of circulating SEA.

Original language	English
Pages (from-to)	30-5
Number of pages	6
Journal	Biochemical medicine and metabolic biology
Volume	41
Issue number	1
Publication status	Published - Feb 1989

Keywords

Acute Disease
Anemia, Hemolytic
Animals
Disease Models, Animal
Erythropoiesis
Hemoglobins
Phenylhydrazines
Rabbits

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@article{81b21568bafd4f50af7c28923f570612,

title = "Serum erythropoietic activity in acute anemia--an animal model",

abstract = "Serum erythropoietic activity and reticulocyte response to anemia were investigated using a rabbit model. In hemolytic anemia, induced by injections of phenylhydrazine on Day 0 the hemoglobin reached a nadir (mean, 6.23 g/dl) on Day 4 when SEA was maximal (mean, 765 mU/ml). In animals venesected on Day 0 and Day 1 to produce anemia of equal severity, the SEA was maximal (mean 235 mU/ml) on Day 2. In both groups the reticulocyte response peaked on Day 7--at 34% for the hemolytic group and 21% for the venesected group. The 2,3-diphosphoglycerate, measured on Day 4, was significantly reduced in the PHZ-treated group. In the venesected group the 2,3-DPG increased between Day 0 and Day 4. There were no concurrent changes in acid-base balance. These results imply that the degree of anemia is only one of the factors which influence the level of circulating SEA.",

keywords = "Acute Disease, Anemia, Hemolytic, Animals, Disease Models, Animal, Erythropoiesis, Hemoglobins, Phenylhydrazines, Rabbits",

author = "McMullin, {M F} and Lappin, {T R} and Elder, {G E} and T Taylor and Bridges, {J M}",

year = "1989",

month = feb,

language = "English",

volume = "41",

pages = "30--5",

journal = "Biochemical medicine and metabolic biology",

issn = "0885-4505",

publisher = "Academic Press Inc.",

number = "1",

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TY - JOUR

T1 - Serum erythropoietic activity in acute anemia--an animal model

AU - McMullin, M F

AU - Lappin, T R

AU - Elder, G E

AU - Taylor, T

AU - Bridges, J M

PY - 1989/2

Y1 - 1989/2

N2 - Serum erythropoietic activity and reticulocyte response to anemia were investigated using a rabbit model. In hemolytic anemia, induced by injections of phenylhydrazine on Day 0 the hemoglobin reached a nadir (mean, 6.23 g/dl) on Day 4 when SEA was maximal (mean, 765 mU/ml). In animals venesected on Day 0 and Day 1 to produce anemia of equal severity, the SEA was maximal (mean 235 mU/ml) on Day 2. In both groups the reticulocyte response peaked on Day 7--at 34% for the hemolytic group and 21% for the venesected group. The 2,3-diphosphoglycerate, measured on Day 4, was significantly reduced in the PHZ-treated group. In the venesected group the 2,3-DPG increased between Day 0 and Day 4. There were no concurrent changes in acid-base balance. These results imply that the degree of anemia is only one of the factors which influence the level of circulating SEA.

AB - Serum erythropoietic activity and reticulocyte response to anemia were investigated using a rabbit model. In hemolytic anemia, induced by injections of phenylhydrazine on Day 0 the hemoglobin reached a nadir (mean, 6.23 g/dl) on Day 4 when SEA was maximal (mean, 765 mU/ml). In animals venesected on Day 0 and Day 1 to produce anemia of equal severity, the SEA was maximal (mean 235 mU/ml) on Day 2. In both groups the reticulocyte response peaked on Day 7--at 34% for the hemolytic group and 21% for the venesected group. The 2,3-diphosphoglycerate, measured on Day 4, was significantly reduced in the PHZ-treated group. In the venesected group the 2,3-DPG increased between Day 0 and Day 4. There were no concurrent changes in acid-base balance. These results imply that the degree of anemia is only one of the factors which influence the level of circulating SEA.

KW - Acute Disease

KW - Anemia, Hemolytic

KW - Animals

KW - Disease Models, Animal

KW - Erythropoiesis

KW - Hemoglobins

KW - Phenylhydrazines

KW - Rabbits

M3 - Article

C2 - 2713149

VL - 41

SP - 30

EP - 35

JO - Biochemical medicine and metabolic biology

JF - Biochemical medicine and metabolic biology

SN - 0885-4505

IS - 1

ER -