Serum Fatty Acid Binding Protein 4 (FABP4) Predicts Pre-eclampsia in Women with Type 1 Diabetes

Amy C. Wotherspoon, Ian S. Young, David R. McCance, Chris C. Patterson, Michael J A Maresh, Donald W M Pearson, James D. Walker, Valerie A. Holmes

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Abstract

Objective: To examine the association between fatty acid binding protein 4 (FABP4) and pre-eclampsia risk in women with type 1 diabetes.
Reesearch Design and Methods: Serum FABP4 was measured in 710 women from the Diabetes and Pre-eclampsia Intervention Trial (DAPIT) in early pregnancy and in the second trimester (median 14 and 26 weeks gestation, respectively).
Results: FABP4 was significantly elevated in early pregnancy (geometric mean 15.8 ng/mL [interquartile range 11.6–21.4] vs. 12.7 ng/mL [interquartile range 9.6–17]; P < 0.001) and the second trimester (18.8 ng/mL [interquartile range 13.6–25.8] vs. 14.6 ng/mL [interquartile range 10.8–19.7]; P < 0.001) in women in whom pre-eclampsia later developed. Elevated second-trimester FABP4 level was independently associated with pre-eclampsia (odds ratio 2.87 [95% CI 1.24, 6.68], P = 0.03). The addition of FABP4 to established risk factors significantly improved net reclassification improvement at both time points and integrated discrimination improvement in the second trimester.
Conclusions: Increased second-trimester FABP4 independently predicted pre-eclampsia and significantly improved reclassification and discrimination. FABP4 shows potential as a novel biomarker for pre-eclampsia prediction in women with type 1 diabetes.
Original languageEnglish
Pages (from-to)1827-1829
Number of pages3
JournalDiabetes Care
Volume39
Issue number10
Early online date14 Sep 2016
DOIs
Publication statusPublished - Oct 2016

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    Wotherspoon, A. C., Young, I. S., McCance, D. R., Patterson, C. C., Maresh, M. J. A., Pearson, D. W. M., Walker, J. D., & Holmes, V. A. (2016). Serum Fatty Acid Binding Protein 4 (FABP4) Predicts Pre-eclampsia in Women with Type 1 Diabetes. Diabetes Care, 39(10), 1827-1829. https://doi.org/10.2337/dc16-0803