Sex-specific effects of protein and carbohydrate intake on reproduction but not lifespan in Drosophila melanogaster

Kim Jensen, Colin McClure, Nicholas K Priest, John Hunt

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

Modest dietary restriction extends lifespan (LS) in a diverse range of taxa and typically has a larger effect in females than males. Traditionally, this has been attributed to a stronger trade-off between LS and reproduction in females than in males that is mediated by the intake of calories. Recent studies, however, suggest that it is the intake of specific nutrients that extends LS and mediates this trade-off. Here, we used the geometric framework (GF) to examine the sex-specific effects of protein (P) and carbohydrate (C) intake on LS and reproduction in Drosophila melanogaster. We found that LS was maximized at a high intake of C and a low intake of P in both sexes, whereas nutrient intake had divergent effects on reproduction. Male offspring production rate and LS were maximized at the same intake of nutrients, whereas female egg production rate was maximized at a high intake of diets with a P:C ratio of 1:2. This resulted in larger differences in nutrient-dependent optima for LS and reproduction in females than in males, as well as an optimal intake of nutrients for lifetime reproduction that differed between the sexes. Under dietary choice, the sexes followed similar feeding trajectories regulated around a P:C ratio of 1:4. Consequently, neither sex reached their nutritional optimum for lifetime reproduction, suggesting intralocus sexual conflict over nutrient optimization. Our study shows clear sex differences in the nutritional requirements of reproduction in D. melanogaster and joins the growing list of studies challenging the role of caloric restriction in extending LS.

Original languageEnglish
Pages (from-to)605-15
Number of pages11
JournalAging cell
Volume14
Issue number4
DOIs
Publication statusPublished - Aug 2015
Externally publishedYes

Bibliographical note

© 2015 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

Keywords

  • Animals
  • Caloric Restriction
  • Clutch Size/drug effects
  • Dietary Carbohydrates/administration & dosage
  • Dietary Proteins/administration & dosage
  • Drosophila melanogaster/drug effects
  • Factor Analysis, Statistical
  • Female
  • Longevity/drug effects
  • Male
  • Reproduction/drug effects
  • Sex Factors
  • Zygote/drug effects

Fingerprint Dive into the research topics of 'Sex-specific effects of protein and carbohydrate intake on reproduction but not lifespan in Drosophila melanogaster'. Together they form a unique fingerprint.

Cite this