Short Report: Engraftment of T-cell-depleted allogeneic haematopoietic stem cells using a reduced intensity conditioning regimen

C Craddock, P Bardy, S Kreiter, R Johnston, J Apperley, D Marks, C Huber, K Kolbe, R Goulding, M Lawler, J Goldman, T Hughes, G Derigs, Mark Lawler

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22 Citations (Scopus)

Abstract

Graft-versus-host disease (GVHD) remains a significant complication in patients undergoing allogeneic stem cell transplantation (SCT) using a reduced intensity conditioning regimen. Although T-cell depletion (TCD) reduces the risk of GVHD after a myeloablative conditioning regimen, it is associated with an increased risk of graft failure. We have therefore examined whether TCD compromises engraftment using a fludarabine-based conditioning regimen. Fifteen patients have been transplanted using such a regimen of whom 13 underwent ex vivo TCD. All but one patient demonstrated durable engraftment and no patient receiving a TCD product developed severe GVHD. Thus, TCD may play a role in GvHD prophylaxis using such regimens.

Original languageEnglish
Pages (from-to)797-800
Number of pages4
JournalBritish Journal of Haematology
Volume111
Issue number3
Publication statusPublished - Dec 2000

Keywords

  • Adult
  • Aged
  • Female
  • Graft vs Host Disease
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Leukemia
  • Lymphocyte Depletion
  • Male
  • Middle Aged
  • Multiple Myeloma
  • T-Lymphocytes
  • Transplantation Conditioning
  • Transplantation, Homologous

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