Abstract
Graft-versus-host disease (GVHD) remains a significant complication in patients undergoing allogeneic stem cell transplantation (SCT) using a reduced intensity conditioning regimen. Although T-cell depletion (TCD) reduces the risk of GVHD after a myeloablative conditioning regimen, it is associated with an increased risk of graft failure. We have therefore examined whether TCD compromises engraftment using a fludarabine-based conditioning regimen. Fifteen patients have been transplanted using such a regimen of whom 13 underwent ex vivo TCD. All but one patient demonstrated durable engraftment and no patient receiving a TCD product developed severe GVHD. Thus, TCD may play a role in GvHD prophylaxis using such regimens.
Original language | English |
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Pages (from-to) | 797-800 |
Number of pages | 4 |
Journal | British Journal of Haematology |
Volume | 111 |
Issue number | 3 |
Publication status | Published - Dec 2000 |
Keywords
- Adult
- Aged
- Female
- Graft vs Host Disease
- Hematopoietic Stem Cell Transplantation
- Humans
- Leukemia
- Lymphocyte Depletion
- Male
- Middle Aged
- Multiple Myeloma
- T-Lymphocytes
- Transplantation Conditioning
- Transplantation, Homologous