Side effects of aminoglycosides on the kidney, ear and balance in cystic fibrosis

Andrew Prayle; Alan Watson; Heather Fortnum; Alan Smyth

doi:10.1136/thx.2009.131532

Side effects of aminoglycosides on the kidney, ear and balance in cystic fibrosis

Andrew Prayle, Alan Watson, Heather Fortnum, Alan Smyth^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

124 Citations (Scopus)

15 Downloads (Pure)

Abstract

Aminoglycoside antibiotics are a central component of the treatment of pulmonary exacerbations of cystic fibrosis (CF) and slow the decline in lung function which ultimately causes the death of most patients. The prognosis of CF has improved, and thus side effects of treatments have become increasingly important. Observational studies suggest that the morbidity from side effects of aminoglycosides is disturbingly common, and that aggressive treatment may lead to more side effects. This review of the current literature on side effects of aminoglycosides considers the pathophysiological mechanisms, epidemiology and risk factors, investigation of side effects and preventative strategies. Treatments which have shown early promise are identified and areas of future research are discussed.

Original language	English
Pages (from-to)	654-658
Number of pages	5
Journal	Thorax
Volume	65
Issue number	7
DOIs	https://doi.org/10.1136/thx.2009.131532
Publication status	Published - 01 Jul 2010
Externally published	Yes

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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10.1136/thx.2009.131532Licence: CC BY-NC

Side effects of aminoglycosides on the kidney, ear and balance in cystic fibrosis
Copyright 2010 BMJ Publishing Group Limited. This is an open access Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits use, distribution and reproduction for non-commercial purposes, provided the author and source are cited.
Final published version, 362 KBLicence: CC BY-NC

Cite this

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abstract = "Aminoglycoside antibiotics are a central component of the treatment of pulmonary exacerbations of cystic fibrosis (CF) and slow the decline in lung function which ultimately causes the death of most patients. The prognosis of CF has improved, and thus side effects of treatments have become increasingly important. Observational studies suggest that the morbidity from side effects of aminoglycosides is disturbingly common, and that aggressive treatment may lead to more side effects. This review of the current literature on side effects of aminoglycosides considers the pathophysiological mechanisms, epidemiology and risk factors, investigation of side effects and preventative strategies. Treatments which have shown early promise are identified and areas of future research are discussed.",

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AU - Watson, Alan

AU - Fortnum, Heather

AU - Smyth, Alan

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AB - Aminoglycoside antibiotics are a central component of the treatment of pulmonary exacerbations of cystic fibrosis (CF) and slow the decline in lung function which ultimately causes the death of most patients. The prognosis of CF has improved, and thus side effects of treatments have become increasingly important. Observational studies suggest that the morbidity from side effects of aminoglycosides is disturbingly common, and that aggressive treatment may lead to more side effects. This review of the current literature on side effects of aminoglycosides considers the pathophysiological mechanisms, epidemiology and risk factors, investigation of side effects and preventative strategies. Treatments which have shown early promise are identified and areas of future research are discussed.

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Side effects of aminoglycosides on the kidney, ear and balance in cystic fibrosis

Abstract

ASJC Scopus subject areas

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