Side effects of genome structural changes.

A Reymond, CN Henrichsen, L Harewood, G Merla

Research output: Contribution to journalArticlepeer-review

67 Citations (Scopus)


The first extensive catalog of structural human variation was recently released. It showed that large stretches of genomic DNA that vary considerably in copy number were extremely abundant. Thus it is conceivable that they play a major role in functional variation. Consistently, genomic insertions and deletions were shown to contribute to phenotypic differences by modifying not only the expression levels of genes within the aneuploid segments but also of normal copy-number neighboring genes. In this report, we review the possible mechanisms behind this latter effect.
Original languageEnglish
JournalCurrent Opinion in Genetics and Development
Publication statusPublished - Oct 2007


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