Significance of NPM1 Gene Mutations in AML

Andrew Hindley, Mark Alexander Catherwood, Mary Frances McMullin, Ken I. Mills

Research output: Contribution to journalLiterature reviewpeer-review

25 Citations (Scopus)
118 Downloads (Pure)

Abstract

The aim of this literature review is to examine the significance of the nucleophosmin 1 (NPM1) gene in acute myeloid leukaemia (AML). This will include analysis of the structure and normal cellular function of NPM1, the type of mutations commonly witnessed in NPM1, and the mechanism by which this influences the development and progression of AML. The importance of NPM1 mutation on prognosis and the treatment options available to patients will also be reviewed along with current guidelines recommending the rapid return of NPM1 mutational screening results and the importance of employing a suitable laboratory assay to achieve this. Finally, future developments in the field including research into new therapies targeting NPM1 mutated AML are considered.
Original languageEnglish
Article number10040
Number of pages16
JournalInternational Journal of Molecular Sciences
Volume22
Issue number18
DOIs
Publication statusPublished - 17 Sept 2021

Keywords

  • AML
  • DNMT3A
  • FLT3
  • NPM1
  • fragment analysis

Fingerprint

Dive into the research topics of 'Significance of NPM1 Gene Mutations in AML'. Together they form a unique fingerprint.

Cite this