Similar Weight Loss Induces Greater Improvements in Insulin Sensitivity and Liver Function among Individuals with NAFLD Compared to Individuals without NAFLD

Ruth Schübel; Tobias Nonnenmacher; Disorn Sookthai; Sandra Gonzalez Maldonado; Solomon A Sowah; Oyunbileg von Stackelberg; Christopher L Schlett; Mirja Grafetstätter; Diana Nabers; Theron Johnson; Romy Kirsten; Cornelia M Ulrich; Rudolf Kaaks; Hans-Ulrich Kauczor; Tilman Kühn; Johanna Nattenmüller

doi:10.3390/nu11030544

Similar Weight Loss Induces Greater Improvements in Insulin Sensitivity and Liver Function among Individuals with NAFLD Compared to Individuals without NAFLD

Ruth Schübel, Tobias Nonnenmacher, Disorn Sookthai, Sandra Gonzalez Maldonado, Solomon A Sowah, Oyunbileg von Stackelberg, Christopher L Schlett, Mirja Grafetstätter, Diana Nabers, Theron Johnson, Romy Kirsten, Cornelia M Ulrich, Rudolf Kaaks, Hans-Ulrich Kauczor, Tilman Kühn, Johanna Nattenmüller

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Abstract

BACKGROUND: Preliminary evidence suggests that weight loss among obese has differential metabolic effects depending on the presence of non-alcoholic fatty liver disease (NAFLD). We assessed whether NAFLD predisposes to differential changes in liver fat content, liver function, and metabolic parameters upon diet-induced weight loss in a 50-week intervention trial.

METHODS: 143 overweight and obese non-smokers underwent a 12-week dietary intervention and a 38-week follow-up. Diet-induced changes in anthropometric measures, circulating biomarkers, and magnetic resonance (MR)-derived liver fat content and adipose tissue volumes were evaluated by mixed linear models stratifying by NAFLD at baseline.

RESULTS: The prevalence of NAFLD at baseline was 52%. Diet-induced weight loss after 12 (NAFLD: 4.8 ± 0.5%, No NAFLD: 5.1 ± 0.5%) and 50 weeks (NAFLD: 3.5 ± 0.7%, No NAFLD: 3.5 ± 0.9%) was similar in both groups, while the decrease in liver fat was significantly greater in the NAFLD group (week 12: 32.9 ± 9.5% vs. 6.3 ± 4.0%; week 50: 23.3 ± 4.4% vs. 5.0 ± 4.2%). Decreases in biomarkers of liver dysfunction (GGT, ALT, AST) and HOMA IR were also significantly greater in the NAFLD group. Other metabolic parameters showed no significant differences.

CONCLUSION: Our data suggest that individuals with NAFLD show greater improvements of liver function and insulin sensitivity after moderate diet-induced weight loss than individuals without NAFLD.

Original language	English
Article number	544
Number of pages	12
Journal	Nutrients
Volume	11
Issue number	3
DOIs	https://doi.org/10.3390/nu11030544
Publication status	Published - 04 Mar 2019
Externally published	Yes

Keywords

Adult
Biomarkers/blood
Diet, Reducing
Female
Humans
Insulin Resistance/physiology
Liver/physiopathology
Male
Middle Aged
Non-alcoholic Fatty Liver Disease/diet therapy
Obesity/complications
Treatment Outcome
Weight Loss/physiology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/nu11030544Licence: CC BY

Similar Weight Loss Induces Greater Improvements in Insulin Sensitivity and Liver Function among Individuals with NAFLD Compared to Individuals without NAFLD
© 2020 The Authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 1.2 MBLicence: CC BY

Cite this

Schübel, R., Nonnenmacher, T., Sookthai, D., Gonzalez Maldonado, S., Sowah, S. A., von Stackelberg, O., Schlett, C. L., Grafetstätter, M., Nabers, D., Johnson, T., Kirsten, R., Ulrich, C. M., Kaaks, R., Kauczor, H.-U., Kühn, T., & Nattenmüller, J. (2019). Similar Weight Loss Induces Greater Improvements in Insulin Sensitivity and Liver Function among Individuals with NAFLD Compared to Individuals without NAFLD. Nutrients, 11(3), Article 544. https://doi.org/10.3390/nu11030544

@article{c544f8312ccb496ea0628965b165470d,

title = "Similar Weight Loss Induces Greater Improvements in Insulin Sensitivity and Liver Function among Individuals with NAFLD Compared to Individuals without NAFLD",

abstract = "BACKGROUND: Preliminary evidence suggests that weight loss among obese has differential metabolic effects depending on the presence of non-alcoholic fatty liver disease (NAFLD). We assessed whether NAFLD predisposes to differential changes in liver fat content, liver function, and metabolic parameters upon diet-induced weight loss in a 50-week intervention trial.METHODS: 143 overweight and obese non-smokers underwent a 12-week dietary intervention and a 38-week follow-up. Diet-induced changes in anthropometric measures, circulating biomarkers, and magnetic resonance (MR)-derived liver fat content and adipose tissue volumes were evaluated by mixed linear models stratifying by NAFLD at baseline.RESULTS: The prevalence of NAFLD at baseline was 52%. Diet-induced weight loss after 12 (NAFLD: 4.8 ± 0.5%, No NAFLD: 5.1 ± 0.5%) and 50 weeks (NAFLD: 3.5 ± 0.7%, No NAFLD: 3.5 ± 0.9%) was similar in both groups, while the decrease in liver fat was significantly greater in the NAFLD group (week 12: 32.9 ± 9.5% vs. 6.3 ± 4.0%; week 50: 23.3 ± 4.4% vs. 5.0 ± 4.2%). Decreases in biomarkers of liver dysfunction (GGT, ALT, AST) and HOMA IR were also significantly greater in the NAFLD group. Other metabolic parameters showed no significant differences.CONCLUSION: Our data suggest that individuals with NAFLD show greater improvements of liver function and insulin sensitivity after moderate diet-induced weight loss than individuals without NAFLD.",

keywords = "Adult, Biomarkers/blood, Diet, Reducing, Female, Humans, Insulin Resistance/physiology, Liver/physiopathology, Male, Middle Aged, Non-alcoholic Fatty Liver Disease/diet therapy, Obesity/complications, Treatment Outcome, Weight Loss/physiology",

author = "Ruth Sch{\"u}bel and Tobias Nonnenmacher and Disorn Sookthai and {Gonzalez Maldonado}, Sandra and Sowah, {Solomon A} and {von Stackelberg}, Oyunbileg and Schlett, {Christopher L} and Mirja Grafetst{\"a}tter and Diana Nabers and Theron Johnson and Romy Kirsten and Ulrich, {Cornelia M} and Rudolf Kaaks and Hans-Ulrich Kauczor and Tilman K{\"u}hn and Johanna Nattenm{\"u}ller",

year = "2019",

month = mar,

day = "4",

doi = "10.3390/nu11030544",

language = "English",

volume = "11",

journal = "Nutrients",

issn = "2072-6643",

publisher = "MDPI",

number = "3",

}

Schübel, R, Nonnenmacher, T, Sookthai, D, Gonzalez Maldonado, S, Sowah, SA, von Stackelberg, O, Schlett, CL, Grafetstätter, M, Nabers, D, Johnson, T, Kirsten, R, Ulrich, CM, Kaaks, R, Kauczor, H-U, Kühn, T & Nattenmüller, J 2019, 'Similar Weight Loss Induces Greater Improvements in Insulin Sensitivity and Liver Function among Individuals with NAFLD Compared to Individuals without NAFLD', Nutrients, vol. 11, no. 3, 544. https://doi.org/10.3390/nu11030544

TY - JOUR

T1 - Similar Weight Loss Induces Greater Improvements in Insulin Sensitivity and Liver Function among Individuals with NAFLD Compared to Individuals without NAFLD

AU - Schübel, Ruth

AU - Nonnenmacher, Tobias

AU - Sookthai, Disorn

AU - Gonzalez Maldonado, Sandra

AU - Sowah, Solomon A

AU - von Stackelberg, Oyunbileg

AU - Schlett, Christopher L

AU - Grafetstätter, Mirja

AU - Nabers, Diana

AU - Johnson, Theron

AU - Kirsten, Romy

AU - Ulrich, Cornelia M

AU - Kaaks, Rudolf

AU - Kauczor, Hans-Ulrich

AU - Kühn, Tilman

AU - Nattenmüller, Johanna

PY - 2019/3/4

Y1 - 2019/3/4

N2 - BACKGROUND: Preliminary evidence suggests that weight loss among obese has differential metabolic effects depending on the presence of non-alcoholic fatty liver disease (NAFLD). We assessed whether NAFLD predisposes to differential changes in liver fat content, liver function, and metabolic parameters upon diet-induced weight loss in a 50-week intervention trial.METHODS: 143 overweight and obese non-smokers underwent a 12-week dietary intervention and a 38-week follow-up. Diet-induced changes in anthropometric measures, circulating biomarkers, and magnetic resonance (MR)-derived liver fat content and adipose tissue volumes were evaluated by mixed linear models stratifying by NAFLD at baseline.RESULTS: The prevalence of NAFLD at baseline was 52%. Diet-induced weight loss after 12 (NAFLD: 4.8 ± 0.5%, No NAFLD: 5.1 ± 0.5%) and 50 weeks (NAFLD: 3.5 ± 0.7%, No NAFLD: 3.5 ± 0.9%) was similar in both groups, while the decrease in liver fat was significantly greater in the NAFLD group (week 12: 32.9 ± 9.5% vs. 6.3 ± 4.0%; week 50: 23.3 ± 4.4% vs. 5.0 ± 4.2%). Decreases in biomarkers of liver dysfunction (GGT, ALT, AST) and HOMA IR were also significantly greater in the NAFLD group. Other metabolic parameters showed no significant differences.CONCLUSION: Our data suggest that individuals with NAFLD show greater improvements of liver function and insulin sensitivity after moderate diet-induced weight loss than individuals without NAFLD.

AB - BACKGROUND: Preliminary evidence suggests that weight loss among obese has differential metabolic effects depending on the presence of non-alcoholic fatty liver disease (NAFLD). We assessed whether NAFLD predisposes to differential changes in liver fat content, liver function, and metabolic parameters upon diet-induced weight loss in a 50-week intervention trial.METHODS: 143 overweight and obese non-smokers underwent a 12-week dietary intervention and a 38-week follow-up. Diet-induced changes in anthropometric measures, circulating biomarkers, and magnetic resonance (MR)-derived liver fat content and adipose tissue volumes were evaluated by mixed linear models stratifying by NAFLD at baseline.RESULTS: The prevalence of NAFLD at baseline was 52%. Diet-induced weight loss after 12 (NAFLD: 4.8 ± 0.5%, No NAFLD: 5.1 ± 0.5%) and 50 weeks (NAFLD: 3.5 ± 0.7%, No NAFLD: 3.5 ± 0.9%) was similar in both groups, while the decrease in liver fat was significantly greater in the NAFLD group (week 12: 32.9 ± 9.5% vs. 6.3 ± 4.0%; week 50: 23.3 ± 4.4% vs. 5.0 ± 4.2%). Decreases in biomarkers of liver dysfunction (GGT, ALT, AST) and HOMA IR were also significantly greater in the NAFLD group. Other metabolic parameters showed no significant differences.CONCLUSION: Our data suggest that individuals with NAFLD show greater improvements of liver function and insulin sensitivity after moderate diet-induced weight loss than individuals without NAFLD.

KW - Adult

KW - Biomarkers/blood

KW - Diet, Reducing

KW - Female

KW - Humans

KW - Insulin Resistance/physiology

KW - Liver/physiopathology

KW - Male

KW - Middle Aged

KW - Non-alcoholic Fatty Liver Disease/diet therapy

KW - Obesity/complications

KW - Treatment Outcome

KW - Weight Loss/physiology

U2 - 10.3390/nu11030544

DO - 10.3390/nu11030544

M3 - Article

C2 - 30836637

SN - 2072-6643

VL - 11

JO - Nutrients

JF - Nutrients

IS - 3

M1 - 544

ER -

Similar Weight Loss Induces Greater Improvements in Insulin Sensitivity and Liver Function among Individuals with NAFLD Compared to Individuals without NAFLD

Abstract

Keywords

UN SDGs

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