Simple preparation of 8-5 coupled ferulate

Diferulates are important products of ferulate-mediated cross-linking of plant cell walls. Coupling of ferulates by radical mechanisms produces a range of diferulates. One of the major isomers, 8−5-coupled diferulate, can be synthesized by single-electron oxidants, but the yields are relatively low and purification is nontrivial. Significant quantities of this dimer are required for various analytical and reactivity studies. A simpler preparation utilizing the biomimetic peroxidase−H2O2 system allows the production of gram quantities of pure diethyl 8−5-diferulate.