Simvastatin decreases the level of heparin-binding protein in patients with acute lung injury

Daniel F McAuley; Cecilia M O'Kane; Thelma R Craig; Murali Shyamsundar; Heiko Herwald; Karim Dib

doi:10.1186/1471-2466-13-47

Simvastatin decreases the level of heparin-binding protein in patients with acute lung injury

Daniel F McAuley, Cecilia M O'Kane, Thelma R Craig, Murali Shyamsundar, Heiko Herwald, Karim Dib

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

244 Downloads (Pure)

Abstract

Background
Heparin-binding protein is released by neutrophils during inflammation and disrupts the integrity of the alveolar and capillary endothelial barrier implicated in the development of acute lung injury and systemic organ failure. We sought to investigate whether oral administration of simvastatin to patients with acute lung injury reduces plasma heparin-binding protein levels and improves intensive care unit outcome.

Methods
Blood samples were collected from patients with acute lung injury with 48 h of onset of acute lung injury (day 0), day 3, and day 7. Patients were given placebo or 80 mg simvastatin for up to 14 days. Plasma heparin-binding protein levels from patients with acute lung injury and healthy volunteers were measured by ELISA.

Results
Levels of plasma heparin-binding protein were significantly higher in patients with acute lung injury than healthy volunteers on day 0 (p = 0.011). Simvastatin 80 mg administered enterally for 14 days reduced plasma level of heparin-binding protein in patients. Reduced heparin-binding protein was associated with improved intensive care unit survival.

Conclusions
A reduction in heparin-binding protein with simvastatin is a potential mechanism by which the statin may modify outcome from acute lung injury.

Original language	English
Article number	47
Number of pages	6
Journal	BMC Pulmonary Medicine
Volume	13
DOIs	https://doi.org/10.1186/1471-2466-13-47
Publication status	Published - 19 Jul 2013

Keywords

simvastatin, acute lung injury, heparin binding protein

Access to Document

10.1186/1471-2466-13-47Licence: CC BY

Simvastatin decreases the level of heparin-binding protein in patients with acute lung injury
© 2013 The Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Final published version, 549 KBLicence: CC BY

Cite this

@article{dab5d5ddf71d48d4904f70f56e76ddb3,

title = "Simvastatin decreases the level of heparin-binding protein in patients with acute lung injury",

abstract = "BackgroundHeparin-binding protein is released by neutrophils during inflammation and disrupts the integrity of the alveolar and capillary endothelial barrier implicated in the development of acute lung injury and systemic organ failure. We sought to investigate whether oral administration of simvastatin to patients with acute lung injury reduces plasma heparin-binding protein levels and improves intensive care unit outcome.MethodsBlood samples were collected from patients with acute lung injury with 48 h of onset of acute lung injury (day 0), day 3, and day 7. Patients were given placebo or 80 mg simvastatin for up to 14 days. Plasma heparin-binding protein levels from patients with acute lung injury and healthy volunteers were measured by ELISA.ResultsLevels of plasma heparin-binding protein were significantly higher in patients with acute lung injury than healthy volunteers on day 0 (p = 0.011). Simvastatin 80 mg administered enterally for 14 days reduced plasma level of heparin-binding protein in patients. Reduced heparin-binding protein was associated with improved intensive care unit survival.ConclusionsA reduction in heparin-binding protein with simvastatin is a potential mechanism by which the statin may modify outcome from acute lung injury.",

keywords = "simvastatin, acute lung injury, heparin binding protein",

author = "McAuley, {Daniel F} and O'Kane, {Cecilia M} and Craig, {Thelma R} and Murali Shyamsundar and Heiko Herwald and Karim Dib",

year = "2013",

month = jul,

day = "19",

doi = "10.1186/1471-2466-13-47",

language = "English",

volume = "13",

journal = "BMC Pulmonary Medicine",

issn = "1471-2466",

publisher = "BioMed Central",

}

TY - JOUR

T1 - Simvastatin decreases the level of heparin-binding protein in patients with acute lung injury

AU - McAuley, Daniel F

AU - O'Kane, Cecilia M

AU - Craig, Thelma R

AU - Shyamsundar, Murali

AU - Herwald, Heiko

AU - Dib, Karim

PY - 2013/7/19

Y1 - 2013/7/19

N2 - BackgroundHeparin-binding protein is released by neutrophils during inflammation and disrupts the integrity of the alveolar and capillary endothelial barrier implicated in the development of acute lung injury and systemic organ failure. We sought to investigate whether oral administration of simvastatin to patients with acute lung injury reduces plasma heparin-binding protein levels and improves intensive care unit outcome.MethodsBlood samples were collected from patients with acute lung injury with 48 h of onset of acute lung injury (day 0), day 3, and day 7. Patients were given placebo or 80 mg simvastatin for up to 14 days. Plasma heparin-binding protein levels from patients with acute lung injury and healthy volunteers were measured by ELISA.ResultsLevels of plasma heparin-binding protein were significantly higher in patients with acute lung injury than healthy volunteers on day 0 (p = 0.011). Simvastatin 80 mg administered enterally for 14 days reduced plasma level of heparin-binding protein in patients. Reduced heparin-binding protein was associated with improved intensive care unit survival.ConclusionsA reduction in heparin-binding protein with simvastatin is a potential mechanism by which the statin may modify outcome from acute lung injury.

AB - BackgroundHeparin-binding protein is released by neutrophils during inflammation and disrupts the integrity of the alveolar and capillary endothelial barrier implicated in the development of acute lung injury and systemic organ failure. We sought to investigate whether oral administration of simvastatin to patients with acute lung injury reduces plasma heparin-binding protein levels and improves intensive care unit outcome.MethodsBlood samples were collected from patients with acute lung injury with 48 h of onset of acute lung injury (day 0), day 3, and day 7. Patients were given placebo or 80 mg simvastatin for up to 14 days. Plasma heparin-binding protein levels from patients with acute lung injury and healthy volunteers were measured by ELISA.ResultsLevels of plasma heparin-binding protein were significantly higher in patients with acute lung injury than healthy volunteers on day 0 (p = 0.011). Simvastatin 80 mg administered enterally for 14 days reduced plasma level of heparin-binding protein in patients. Reduced heparin-binding protein was associated with improved intensive care unit survival.ConclusionsA reduction in heparin-binding protein with simvastatin is a potential mechanism by which the statin may modify outcome from acute lung injury.

KW - simvastatin, acute lung injury, heparin binding protein

U2 - 10.1186/1471-2466-13-47

DO - 10.1186/1471-2466-13-47

M3 - Article

C2 - 23870614

SN - 1471-2466

VL - 13

JO - BMC Pulmonary Medicine

JF - BMC Pulmonary Medicine

M1 - 47

ER -

Simvastatin decreases the level of heparin-binding protein in patients with acute lung injury

Abstract

Keywords

Access to Document

Fingerprint

Cite this