Small Non-coding RNA Expression Following Respiratory Syncytial Virus or Measles Virus Infection of Neuronal Cells

Abhijeet A Bakre; Catherine Duffy; Hani'ah Abdullah; S Louise Cosby; Ralph A Tripp

doi:10.3389/fmicb.2021.671852

Small Non-coding RNA Expression Following Respiratory Syncytial Virus or Measles Virus Infection of Neuronal Cells

Abhijeet A Bakre, Catherine Duffy, Hani'ah Abdullah, S Louise Cosby, Ralph A Tripp

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Abstract

Respiratory syncytial virus (RSV) or measles virus (MeV) infection modifies host responses through small non-coding RNA (sncRNA) expression. We show that RSV or MeV infection of neuronal cells induces sncRNAs including various microRNAs and transfer RNA fragments (tRFs). We show that these tRFs originate from select tRNAs (GCC and CAC for glycine, CTT and AAC for Valine, and CCC and TTT for Lysine). Some of the tRNAs are rarely used by RSV or MeV as indicated by relative synonymous codon usage indices suggesting selective cleavage of the tRNAs occurs in infected neuronal cells. The data implies that differentially expressed sncRNAs may regulate host gene expression multiple mechanisms in neuronal cells.

Original language	English
Article number	671852
Journal	Frontiers in Microbiology
Volume	12
DOIs	https://doi.org/10.3389/fmicb.2021.671852
Publication status	Published - 03 Sept 2021

Keywords

measles virus
transfer RNAs
piwi-associated RNAs
respiratory syncytial virus
microRNAs
neuronal cells

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10.3389/fmicb.2021.671852Licence: CC BY

Small Non-coding RNA Expression Following Respiratory Syncytial Virus or Measles Virus Infection of Neuronal Cells
Copyright 2021 the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited
Final published version, 1.45 MBLicence: CC BY

Cite this

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title = "Small Non-coding RNA Expression Following Respiratory Syncytial Virus or Measles Virus Infection of Neuronal Cells",

abstract = "Respiratory syncytial virus (RSV) or measles virus (MeV) infection modifies host responses through small non-coding RNA (sncRNA) expression. We show that RSV or MeV infection of neuronal cells induces sncRNAs including various microRNAs and transfer RNA fragments (tRFs). We show that these tRFs originate from select tRNAs (GCC and CAC for glycine, CTT and AAC for Valine, and CCC and TTT for Lysine). Some of the tRNAs are rarely used by RSV or MeV as indicated by relative synonymous codon usage indices suggesting selective cleavage of the tRNAs occurs in infected neuronal cells. The data implies that differentially expressed sncRNAs may regulate host gene expression multiple mechanisms in neuronal cells. ",

keywords = "measles virus, transfer RNAs, piwi-associated RNAs, respiratory syncytial virus, microRNAs, neuronal cells",

author = "Bakre, {Abhijeet A} and Catherine Duffy and Hani'ah Abdullah and Cosby, {S Louise} and Tripp, {Ralph A}",

year = "2021",

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doi = "10.3389/fmicb.2021.671852",

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T1 - Small Non-coding RNA Expression Following Respiratory Syncytial Virus or Measles Virus Infection of Neuronal Cells

AU - Bakre, Abhijeet A

AU - Duffy, Catherine

AU - Abdullah, Hani'ah

AU - Cosby, S Louise

AU - Tripp, Ralph A

PY - 2021/9/3

Y1 - 2021/9/3

N2 - Respiratory syncytial virus (RSV) or measles virus (MeV) infection modifies host responses through small non-coding RNA (sncRNA) expression. We show that RSV or MeV infection of neuronal cells induces sncRNAs including various microRNAs and transfer RNA fragments (tRFs). We show that these tRFs originate from select tRNAs (GCC and CAC for glycine, CTT and AAC for Valine, and CCC and TTT for Lysine). Some of the tRNAs are rarely used by RSV or MeV as indicated by relative synonymous codon usage indices suggesting selective cleavage of the tRNAs occurs in infected neuronal cells. The data implies that differentially expressed sncRNAs may regulate host gene expression multiple mechanisms in neuronal cells.

AB - Respiratory syncytial virus (RSV) or measles virus (MeV) infection modifies host responses through small non-coding RNA (sncRNA) expression. We show that RSV or MeV infection of neuronal cells induces sncRNAs including various microRNAs and transfer RNA fragments (tRFs). We show that these tRFs originate from select tRNAs (GCC and CAC for glycine, CTT and AAC for Valine, and CCC and TTT for Lysine). Some of the tRNAs are rarely used by RSV or MeV as indicated by relative synonymous codon usage indices suggesting selective cleavage of the tRNAs occurs in infected neuronal cells. The data implies that differentially expressed sncRNAs may regulate host gene expression multiple mechanisms in neuronal cells.

KW - measles virus

KW - transfer RNAs

KW - piwi-associated RNAs

KW - respiratory syncytial virus

KW - microRNAs

KW - neuronal cells

U2 - 10.3389/fmicb.2021.671852

DO - 10.3389/fmicb.2021.671852

M3 - Article

C2 - 34539595

SN - 1664-302X

VL - 12

JO - Frontiers in Microbiology

JF - Frontiers in Microbiology

M1 - 671852

ER -

Small Non-coding RNA Expression Following Respiratory Syncytial Virus or Measles Virus Infection of Neuronal Cells

Abstract

Keywords

UN SDGs

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