Smart Responsive Microarray Patches for Transdermal Drug Delivery and Biological Monitoring

Li Zhao, Chunyang Zhang, Juhaina M. Abu‐Ershaid, Mingshan Li, Yaocun Li, Yara Naser, Xianbing Dai, Marco T. A. Abbate, Ryan F. Donnelly

Research output: Contribution to journalReview articlepeer-review


Traditional drug delivery routes possess various disadvantages which make them unsuitable for certain population groups, or indeed unsuitable for drugs with certain physicochemical properties. As a result, a variety of alternative drug delivery routes have been explored in recent decades, including transdermal drug delivery. One of the most promising novel transdermal drug delivery technologies is a microarray patch (MAP), which can bypass the outermost skin barrier and deliver drugs directly into the viable epidermis and dermis. Unlike traditional MAPs which release loaded cargo simultaneously upon insertion into the skin, stimuli responsive MAPs based on biological stimuli are able to precisely release the drug in response to the need for additional doses. Thus, smart MAPs that are only responsive to certain external stimuli are highly desirable, as they provide safer and more efficient drug delivery. In addition to drug delivery, they can also be used for biological monitoring, which further expands their applications.
Original languageEnglish
Article number2100996
JournalAdvanced Healthcare Materials
Early online date27 Aug 2021
Publication statusEarly online date - 27 Aug 2021


  • biological monitoring
  • drug delivery
  • microarray patches
  • responsive patches
  • transdermal patches


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