Abstract
Traditional drug delivery routes possess various disadvantages which make them unsuitable for certain population groups, or indeed unsuitable for drugs with certain physicochemical properties. As a result, a variety of alternative drug delivery routes have been explored in recent decades, including transdermal drug delivery. One of the most promising novel transdermal drug delivery technologies is a microarray patch (MAP), which can bypass the outermost skin barrier and deliver drugs directly into the viable epidermis and dermis. Unlike traditional MAPs which release loaded cargo simultaneously upon insertion into the skin, stimuli responsive MAPs based on biological stimuli are able to precisely release the drug in response to the need for additional doses. Thus, smart MAPs that are only responsive to certain external stimuli are highly desirable, as they provide safer and more efficient drug delivery. In addition to drug delivery, they can also be used for biological monitoring, which further expands their applications.
Original language | English |
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Article number | 2100996 |
Journal | Advanced Healthcare Materials |
Early online date | 27 Aug 2021 |
DOIs | |
Publication status | Early online date - 27 Aug 2021 |
Keywords
- biological monitoring
- drug delivery
- microarray patches
- responsive patches
- transdermal patches
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Development of dissolving microneedles for intradermal delivery of the long-acting antiretroviral drug bictegravir
Author: Zhang, C., Dec 2022Supervisor: Donnelly, R. (Supervisor) & Larraneta Landa, E. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy