Solid-Phase Synthesis Of Oligonucleotides Containing 3'-Thiothymidine

R. Cosstick; Joseph Vyle

doi:10.1016/S0040-4039(01)80776-0

Solid-Phase Synthesis Of Oligonucleotides Containing 3'-Thiothymidine

R. Cosstick, Joseph Vyle

School of Chemistry and Chemical Engineering

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

A 5'-O-monomethoxytritylthymidine-3'-S-thiophosphoramidite (3) has been used to prepare oligodeoxynucleotides containing 3'-thiothymidine on a solid phase support. The intermediate thiophosphites are most efficiently oxidised using tetrabutylammonium periodate.

Original language	English
Pages (from-to)	4693-4696
Number of pages	4
Journal	Tetrahedron Letters
Volume	30 (35)
DOIs	https://doi.org/10.1016/S0040-4039(01)80776-0
Publication status	Published - 1989

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10.1016/S0040-4039(01)80776-0

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@article{4cfd9580b03842ab925cae848916d4cb,

title = "Solid-Phase Synthesis Of Oligonucleotides Containing 3'-Thiothymidine",

abstract = "A 5'-O-monomethoxytritylthymidine-3'-S-thiophosphoramidite (3) has been used to prepare oligodeoxynucleotides containing 3'-thiothymidine on a solid phase support. The intermediate thiophosphites are most efficiently oxidised using tetrabutylammonium periodate.",

author = "R. Cosstick and Joseph Vyle",

year = "1989",

doi = "10.1016/S0040-4039(01)80776-0",

language = "English",

volume = "30 (35)",

pages = "4693--4696",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd",

}

TY - JOUR

T1 - Solid-Phase Synthesis Of Oligonucleotides Containing 3'-Thiothymidine

AU - Cosstick, R.

AU - Vyle, Joseph

PY - 1989

Y1 - 1989

N2 - A 5'-O-monomethoxytritylthymidine-3'-S-thiophosphoramidite (3) has been used to prepare oligodeoxynucleotides containing 3'-thiothymidine on a solid phase support. The intermediate thiophosphites are most efficiently oxidised using tetrabutylammonium periodate.

AB - A 5'-O-monomethoxytritylthymidine-3'-S-thiophosphoramidite (3) has been used to prepare oligodeoxynucleotides containing 3'-thiothymidine on a solid phase support. The intermediate thiophosphites are most efficiently oxidised using tetrabutylammonium periodate.

U2 - 10.1016/S0040-4039(01)80776-0

DO - 10.1016/S0040-4039(01)80776-0

M3 - Article

SN - 0040-4039

VL - 30 (35)

SP - 4693

EP - 4696

JO - Tetrahedron Letters

JF - Tetrahedron Letters

ER -

Solid-Phase Synthesis Of Oligonucleotides Containing 3'-Thiothymidine

Abstract

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