Solubility study of tobramycin in room temperature ionic liquids: an experimental and computational based study

Richard Cunningham; Nancy C. Forero-Martinez; Christopher Hardacre; Tristan G. A. Youngs; Marie E. Migaud

doi:10.1039/c6ra23078d

Solubility study of tobramycin in room temperature ionic liquids: an experimental and computational based study

Richard Cunningham^*, Nancy C. Forero-Martinez, Christopher Hardacre, Tristan G. A. Youngs, Marie E. Migaud

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Herein, we present a computational and experimental study assessing the solubility of tobramycin 1 in a series of hydrophilic room temperature ionic liquids (RTIL). We show that hydrophilic ionic liquids, in particular those containing acetate, [OAc]⁻, enable significantly enhanced solubilisation of tobramycin in comparison to conventional molecular solvents.

Original language	English
Pages (from-to)	107214-107218
Number of pages	5
Journal	RSC Advances
Volume	6
Issue number	109
Early online date	04 Nov 2016
DOIs	https://doi.org/10.1039/c6ra23078d
Publication status	Published - 2016

ASJC Scopus subject areas

General Chemistry
General Chemical Engineering

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title = "Solubility study of tobramycin in room temperature ionic liquids: an experimental and computational based study",

abstract = "Herein, we present a computational and experimental study assessing the solubility of tobramycin 1 in a series of hydrophilic room temperature ionic liquids (RTIL). We show that hydrophilic ionic liquids, in particular those containing acetate, [OAc]−, enable significantly enhanced solubilisation of tobramycin in comparison to conventional molecular solvents.",

author = "Richard Cunningham and Forero-Martinez, {Nancy C.} and Christopher Hardacre and Youngs, {Tristan G. A.} and Migaud, {Marie E.}",

year = "2016",

doi = "10.1039/c6ra23078d",

language = "English",

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pages = "107214--107218",

journal = "RSC Advances",

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publisher = "Royal Society of Chemistry",

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T1 - Solubility study of tobramycin in room temperature ionic liquids: an experimental and computational based study

AU - Cunningham, Richard

AU - Forero-Martinez, Nancy C.

AU - Hardacre, Christopher

AU - Youngs, Tristan G. A.

AU - Migaud, Marie E.

PY - 2016

Y1 - 2016

N2 - Herein, we present a computational and experimental study assessing the solubility of tobramycin 1 in a series of hydrophilic room temperature ionic liquids (RTIL). We show that hydrophilic ionic liquids, in particular those containing acetate, [OAc]−, enable significantly enhanced solubilisation of tobramycin in comparison to conventional molecular solvents.

AB - Herein, we present a computational and experimental study assessing the solubility of tobramycin 1 in a series of hydrophilic room temperature ionic liquids (RTIL). We show that hydrophilic ionic liquids, in particular those containing acetate, [OAc]−, enable significantly enhanced solubilisation of tobramycin in comparison to conventional molecular solvents.

UR - http://www.scopus.com/inward/record.url?scp=84995876948&partnerID=8YFLogxK

U2 - 10.1039/c6ra23078d

DO - 10.1039/c6ra23078d

M3 - Article

AN - SCOPUS:84995876948

SN - 2046-2069

VL - 6

SP - 107214

EP - 107218

JO - RSC Advances

JF - RSC Advances

IS - 109

ER -

Solubility study of tobramycin in room temperature ionic liquids: an experimental and computational based study

Abstract

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