Soluble endostatin is a novel inhibitor of epithelial repair in idiopathic pulmonary fibrosis

A.G. Richter; S. McKeown; S. Rathinam; L. Harper; P. Rajesh; Danny McAuley; R. Heljasvaara; D.R. Thickett

doi:10.1136/thx.2008.102814

Soluble endostatin is a novel inhibitor of epithelial repair in idiopathic pulmonary fibrosis

A.G. Richter, S. McKeown, S. Rathinam, L. Harper, P. Rajesh, Danny McAuley, R. Heljasvaara, D.R. Thickett

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

Background and aim: Aberrant angiogenesis and defective epithelial repair are key features of idiopathic pulmonary fibrosis (IPF). Endostatin is an antiangiogenic peptide with known effects on endothelial cells. This study aimed to establish the levels of endostatin in the bronchoalveolar lavage fluid (BALF) in IPF and to investigate its actions on distal lung epithelial cells (DLEC) and primary type II cells.

Original language	English
Pages (from-to)	156-161
Number of pages	6
Journal	Thorax
Volume	64
Issue number	2
DOIs	https://doi.org/10.1136/thx.2008.102814
Publication status	Published - Feb 2009

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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10.1136/thx.2008.102814

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abstract = "Background and aim: Aberrant angiogenesis and defective epithelial repair are key features of idiopathic pulmonary fibrosis (IPF). Endostatin is an antiangiogenic peptide with known effects on endothelial cells. This study aimed to establish the levels of endostatin in the bronchoalveolar lavage fluid (BALF) in IPF and to investigate its actions on distal lung epithelial cells (DLEC) and primary type II cells.",

author = "A.G. Richter and S. McKeown and S. Rathinam and L. Harper and P. Rajesh and Danny McAuley and R. Heljasvaara and D.R. Thickett",

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AU - McKeown, S.

AU - Rathinam, S.

AU - Harper, L.

AU - Rajesh, P.

AU - McAuley, Danny

AU - Heljasvaara, R.

AU - Thickett, D.R.

PY - 2009/2

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N2 - Background and aim: Aberrant angiogenesis and defective epithelial repair are key features of idiopathic pulmonary fibrosis (IPF). Endostatin is an antiangiogenic peptide with known effects on endothelial cells. This study aimed to establish the levels of endostatin in the bronchoalveolar lavage fluid (BALF) in IPF and to investigate its actions on distal lung epithelial cells (DLEC) and primary type II cells.

AB - Background and aim: Aberrant angiogenesis and defective epithelial repair are key features of idiopathic pulmonary fibrosis (IPF). Endostatin is an antiangiogenic peptide with known effects on endothelial cells. This study aimed to establish the levels of endostatin in the bronchoalveolar lavage fluid (BALF) in IPF and to investigate its actions on distal lung epithelial cells (DLEC) and primary type II cells.

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DO - 10.1136/thx.2008.102814

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Soluble endostatin is a novel inhibitor of epithelial repair in idiopathic pulmonary fibrosis

Abstract

ASJC Scopus subject areas

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