Soluble P-selectin levels during normal pregnancy: a longitudinal study.

Valerie Holmes, J.M.W. Wallace, W.S. Gilmore, P. McFaul, H.D. Alexander

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Objective: To investigate soluble P-selectin (sP-selectin) levels and platelet parameters in normal pregnant women compared with non-pregnant control subjects. Design: A longitudinal case-control study. Setting: Obstetric outpatient clinic in the Jubilee Maternity Hospital, Belfast. Population: One hundred and twenty normal pregnant women and 41 non-pregnant age matched control subjects. Main outcome measures Plasma sP-selectin as a measure of platelet activation in normal pregnancy. Methods: The plasma concentration of sP-selectin in pregnant women sampled at 12, 20 and 35 weeks of gestation, and, in a subgroup at 3 days post-partum, and non-pregnant controls sampled in parallel, was determined using a commercial quantitative sandwich immunoassay kit. Platelet parameters on each blood sample were also recorded using a SYSMEX SE 9500 analyser. Main outcome measures: Plasma sP-selectin as a measure of platelet activation in normal pregnancy. Results: Soluble P-selectin was significantly higher in pregnant women than in non-pregnant control subjects at 20 and 35 weeks of gestation, (p
Original languageEnglish
Pages (from-to)997-1002
Number of pages6
JournalBJOG: An International Journal of Obstetrics and Gynaecology
Volume109(9)
Issue number9
DOIs
Publication statusPublished - Sep 2002

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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