Results: We describe the structure of the large extracellular domain of Sm-TSP-2, develop a model of its interactions with Tetraspanin-enriched-microdomain proteins and plasma membrane, and identify TEM constituents.
Conclusion: Structural conservation of the domain means this model is likely applicable to TSPs in general.
Significance: Tetraspanin-enriched-microdomain proteins provide further targets for multiplex vaccines and/or novel drug targets.
ASJC Scopus subject areas
- Cell Biology
- Molecular Biology