Solvent-Free, Continuous Synthesis of Hydrazone-Based Active Pharmaceutical Ingredients by Twin-Screw Extrusion

Deborah E. Crawford; Andrea Porcheddu; Aaron S. McCalmont; Francesco Delogu; Stuart L. James; Evelina Colacino

doi:10.1021/acssuschemeng.0c03816

Solvent-Free, Continuous Synthesis of Hydrazone-Based Active Pharmaceutical Ingredients by Twin-Screw Extrusion

Deborah E. Crawford, Andrea Porcheddu, Aaron S. McCalmont, Francesco Delogu, Stuart L. James, Evelina Colacino

School of Chemistry and Chemical Engineering

Research output: Contribution to journal › Article › peer-review

86 Citations (Scopus)

235 Downloads (Pure)

Abstract

Twin-screw extrusion (TSE) was used to synthesize hydantoin-based active pharmaceutical ingredients (APIs) such as nitrofurantoin and dantrolene, employing minimal or no solvent. Postsynthetic workup was not required. This work demonstrates that solvent-free synthesis can be conducted in a continuous manner for pharmaceutical products.

Original language	English
Pages (from-to)	12230-12238
Number of pages	9
Journal	ACS Sustainable Chemistry & Engineering
Volume	8
Issue number	32
Early online date	05 Aug 2020
DOIs	https://doi.org/10.1021/acssuschemeng.0c03816
Publication status	Published - 17 Aug 2020

Keywords

Renewable Energy, Sustainability and the Environment
General Chemical Engineering
Environmental Chemistry
General Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/acssuschemeng.0c03816Licence: CC BY-NC

Solvent-Free, Continuous Synthesis of Hydrazone-Based Active Pharmaceutical Ingredients by Twin-Screw Extrusion
© 2020 American Chemical Society This is an open access Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits use, distribution and reproduction for non-commercial purposes, provided the author and source are cited
Final published version, 4.03 MBLicence: CC BY-NC

Cite this

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abstract = "Twin-screw extrusion (TSE) was used to synthesize hydantoin-based active pharmaceutical ingredients (APIs) such as nitrofurantoin and dantrolene, employing minimal or no solvent. Postsynthetic workup was not required. This work demonstrates that solvent-free synthesis can be conducted in a continuous manner for pharmaceutical products.",

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AU - Crawford, Deborah E.

AU - Porcheddu, Andrea

AU - McCalmont, Aaron S.

AU - Delogu, Francesco

AU - James, Stuart L.

AU - Colacino, Evelina

PY - 2020/8/17

Y1 - 2020/8/17

N2 - Twin-screw extrusion (TSE) was used to synthesize hydantoin-based active pharmaceutical ingredients (APIs) such as nitrofurantoin and dantrolene, employing minimal or no solvent. Postsynthetic workup was not required. This work demonstrates that solvent-free synthesis can be conducted in a continuous manner for pharmaceutical products.

AB - Twin-screw extrusion (TSE) was used to synthesize hydantoin-based active pharmaceutical ingredients (APIs) such as nitrofurantoin and dantrolene, employing minimal or no solvent. Postsynthetic workup was not required. This work demonstrates that solvent-free synthesis can be conducted in a continuous manner for pharmaceutical products.

KW - Renewable Energy, Sustainability and the Environment

KW - General Chemical Engineering

KW - Environmental Chemistry

KW - General Chemistry

U2 - 10.1021/acssuschemeng.0c03816

DO - 10.1021/acssuschemeng.0c03816

M3 - Article

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JO - ACS Sustainable Chemistry & Engineering

JF - ACS Sustainable Chemistry & Engineering

IS - 32

ER -

Solvent-Free, Continuous Synthesis of Hydrazone-Based Active Pharmaceutical Ingredients by Twin-Screw Extrusion

Abstract

Keywords

UN SDGs

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