Solvent- free sonochemistry as a route to pharmaceutical co- crystals

David Roy, Stuart James, Deborah Crawford

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


We describe the synthesis of pharmaceutically relevant co-crystals by solvent-free sonochemistry starting from solid reagents. Employing a standard ultrasonic cleaning bath, quantitative conversions occurred within 20-60 minutes to give co-crystals of paracetamol and aspirin with a range of co-formers. As well as the utility of the method, the work raises interesting mechanistic questions regarding acoustic cavitation with no liquid phase being present.
Original languageEnglish
Pages (from-to)5463-5466
Number of pages4
JournalChemical Communications
Issue number38
Publication statusPublished - 11 May 2019


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