Abstract
We describe the synthesis of pharmaceutically relevant co-crystals by solvent-free sonochemistry starting from solid reagents. Employing a standard ultrasonic cleaning bath, quantitative conversions occurred within 20-60 minutes to give co-crystals of paracetamol and aspirin with a range of co-formers. As well as the utility of the method, the work raises interesting mechanistic questions regarding acoustic cavitation with no liquid phase being present.
| Original language | English |
|---|---|
| Pages (from-to) | 5463-5466 |
| Number of pages | 4 |
| Journal | Chemical Communications |
| Volume | 55 |
| Issue number | 38 |
| DOIs | |
| Publication status | Published - 11 May 2019 |