Solvent-free synthesis of metal complexes

A.L. Garay, A. Pichon, Stuart James

Research output: Contribution to journalArticlepeer-review

442 Citations (Scopus)


Avoiding the use of solvents in synthesis can reduce environmental contamination and even be more convenient than using solvent-based synthesis. In this tutorial review we focus on recent research into the use of mechanochemistry ( grinding) to synthesise metal complexes in the absence of solvent. We include synthesis of mononuclear complexes, coordination clusters, spacious coordination cages, and 1-, 2- and 3-dimensional coordination polymers ( metal organic frameworks) which can even exhibit microporosity. Remarkably, in many cases, mechanochemical synthesis is actually faster and more convenient than the original solvent-based methods. Examples of solvent-free methods other than grinding are also briefly discussed, and the positive outlook for this growing topic is emphasised.
Original languageEnglish
Pages (from-to)846-855
Number of pages10
JournalChemical Society Reviews
Issue number6
Publication statusPublished - 2007

ASJC Scopus subject areas

  • Chemistry(all)

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