Solventless synthesis of acyl phosphonamidates, precursors to masked bisphosphonates

Kerri Crossey, Marie E. Migaud*

*Corresponding author for this work

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A series of acyl phosphonamidates, the synthetic precursors to bisphosphonates, have been readily prepared from phosphoramidite type reagents and a range of acid chlorides. These reactions were performed using solventless conditions, where purification was easily achieved using column chromatography with yields ranging from 71-90%. Furthermore, we have demonstrated that these acyl phosphonamidates could be used for the preparation of unsymmetrical bisphosphonates, which do date are scarcely reported in the literature.
Original languageEnglish
Pages (from-to)11088-11091
Number of pages4
JournalChemical Communications
Volume51
Issue number55
Early online date09 Jun 2015
DOIs
Publication statusPublished - 14 Jul 2015

Keywords

  • ALPHA-KETOPHOSPHONATES
  • ANTICANCER ACTIVITY
  • EFFICIENT METHOD
  • DERIVATIVES
  • ESTERS
  • PRODRUGS
  • PHOSPHORODIAMIDITES
  • PHOSPHONATES
  • NUCLEOSIDE
  • ETIDRONATE

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Ceramics and Composites
  • Electronic, Optical and Magnetic Materials
  • Surfaces, Coatings and Films
  • Materials Chemistry
  • Metals and Alloys

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