Splicing of histone deacetylase 7 modulates smooth muscle cell proliferation and neointima formation through nuclear β-catenin translocation

Boda Zhou; Andriana Margariti; Lingfang Zeng; Ouassila Habi; Qingzhong Xiao; Daniel Martin; Gang Wang; Yanhua Hu; Xian Wang; Qingbo Xu

doi:10.1161/ATVBAHA.111.230888

Splicing of histone deacetylase 7 modulates smooth muscle cell proliferation and neointima formation through nuclear β-catenin translocation

Boda Zhou, Andriana Margariti, Lingfang Zeng, Ouassila Habi, Qingzhong Xiao, Daniel Martin, Gang Wang, Yanhua Hu, Xian Wang, Qingbo Xu

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Vascular smooth muscle cell (SMC) proliferation has an indispensable role in the pathogenesis of vascular disease, but the mechanism is not fully elucidated. The epigenetic enzyme histone deacetylase 7 (HDAC7) is involved in endothelial homeostasis and SMC differentiation and could have a role in SMC proliferation. In this study, we sought to examine the effect of 2 HDAC7 isoforms on SMC proliferation and neointima formation.

Original language	English
Pages (from-to)	2676-84
Number of pages	9
Journal	Arteriosclerosis Thrombosis and Vascular Biology
Volume	31
Issue number	11
DOIs	https://doi.org/10.1161/ATVBAHA.111.230888
Publication status	Published - 2011

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10.1161/ATVBAHA.111.230888

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title = "Splicing of histone deacetylase 7 modulates smooth muscle cell proliferation and neointima formation through nuclear β-catenin translocation",

abstract = "Vascular smooth muscle cell (SMC) proliferation has an indispensable role in the pathogenesis of vascular disease, but the mechanism is not fully elucidated. The epigenetic enzyme histone deacetylase 7 (HDAC7) is involved in endothelial homeostasis and SMC differentiation and could have a role in SMC proliferation. In this study, we sought to examine the effect of 2 HDAC7 isoforms on SMC proliferation and neointima formation.",

author = "Boda Zhou and Andriana Margariti and Lingfang Zeng and Ouassila Habi and Qingzhong Xiao and Daniel Martin and Gang Wang and Yanhua Hu and Xian Wang and Qingbo Xu",

year = "2011",

doi = "10.1161/ATVBAHA.111.230888",

language = "English",

volume = "31",

pages = "2676--84",

journal = "Arteriosclerosis Thrombosis and Vascular Biology",

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TY - JOUR

T1 - Splicing of histone deacetylase 7 modulates smooth muscle cell proliferation and neointima formation through nuclear β-catenin translocation

AU - Zhou, Boda

AU - Margariti, Andriana

AU - Zeng, Lingfang

AU - Habi, Ouassila

AU - Xiao, Qingzhong

AU - Martin, Daniel

AU - Wang, Gang

AU - Hu, Yanhua

AU - Wang, Xian

AU - Xu, Qingbo

PY - 2011

Y1 - 2011

N2 - Vascular smooth muscle cell (SMC) proliferation has an indispensable role in the pathogenesis of vascular disease, but the mechanism is not fully elucidated. The epigenetic enzyme histone deacetylase 7 (HDAC7) is involved in endothelial homeostasis and SMC differentiation and could have a role in SMC proliferation. In this study, we sought to examine the effect of 2 HDAC7 isoforms on SMC proliferation and neointima formation.

AB - Vascular smooth muscle cell (SMC) proliferation has an indispensable role in the pathogenesis of vascular disease, but the mechanism is not fully elucidated. The epigenetic enzyme histone deacetylase 7 (HDAC7) is involved in endothelial homeostasis and SMC differentiation and could have a role in SMC proliferation. In this study, we sought to examine the effect of 2 HDAC7 isoforms on SMC proliferation and neointima formation.

U2 - 10.1161/ATVBAHA.111.230888

DO - 10.1161/ATVBAHA.111.230888

M3 - Article

C2 - 21836063

SN - 1524-4636

VL - 31

SP - 2676

EP - 2684

JO - Arteriosclerosis Thrombosis and Vascular Biology

JF - Arteriosclerosis Thrombosis and Vascular Biology

IS - 11

ER -

Splicing of histone deacetylase 7 modulates smooth muscle cell proliferation and neointima formation through nuclear β-catenin translocation

Abstract

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