Splicing of histone deacetylase 7 modulates smooth muscle cell proliferation and neointima formation through nuclear β-catenin translocation

Boda Zhou, Andriana Margariti, Lingfang Zeng, Ouassila Habi, Qingzhong Xiao, Daniel Martin, Gang Wang, Yanhua Hu, Xian Wang, Qingbo Xu

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Vascular smooth muscle cell (SMC) proliferation has an indispensable role in the pathogenesis of vascular disease, but the mechanism is not fully elucidated. The epigenetic enzyme histone deacetylase 7 (HDAC7) is involved in endothelial homeostasis and SMC differentiation and could have a role in SMC proliferation. In this study, we sought to examine the effect of 2 HDAC7 isoforms on SMC proliferation and neointima formation.
Original languageEnglish
Pages (from-to)2676-84
Number of pages9
JournalArteriosclerosis Thrombosis and Vascular Biology
Volume31
Issue number11
DOIs
Publication statusPublished - 2011

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