STC-1 Cells

Triona McCarthy, Brian D Green, Danielle Calderwood, Anna Gillespie, John F Cryan, Linda Giblin

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

3 Citations (Scopus)
2978 Downloads (Pure)

Abstract

Gastrointestinal hormones such as cholecystokinin (CCK), glucagon like peptide 1 (GLP-1), and peptide YY (PYY) play an important role in suppressing hunger and controlling food intake. These satiety hormones are secreted from enteroendocrine cells present throughout the intestinal tract. The intestinal secretin tumor cell line (STC-1) possesses many features of native intestinal enteroendocrine cells. As such, STC-1 cells are routinely used in screening platforms to identify foods or compounds that modulate secretion of gastrointestinal hormones in vitro. This chapter describes this intestinal cell model focussing on it’s applications, advantages and limitations. A general protocol is provided for challenging STC-1 cells with test compounds.
Original languageEnglish
Title of host publicationThe Impact of Food Bioactives on Health: in vitro and ex vivo models
EditorsKitty Verhoeckx, Paul Cotter, Iván López-Expósito, Charlotte Kleiveland, Tor Lea, Alan Mackie, Teresa Requena, Dominika Swiatecka, Harry Wichers
PublisherSpringer
Pages211-220
Number of pages20
VolumePart IV
ISBN (Electronic)9783319161044
ISBN (Print)9783319157917
DOIs
Publication statusPublished - 2015

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    McCarthy, T., Green, B. D., Calderwood, D., Gillespie, A., Cryan, J. F., & Giblin, L. (2015). STC-1 Cells. In K. Verhoeckx, P. Cotter, I. López-Expósito, C. Kleiveland, T. Lea, A. Mackie, T. Requena, D. Swiatecka, & H. Wichers (Eds.), The Impact of Food Bioactives on Health: in vitro and ex vivo models (Vol. Part IV, pp. 211-220). Springer. https://doi.org/10.1007/978-3-319-16104-4_19