STC-1 Cells

Triona McCarthy; Brian D Green; Danielle Calderwood; Anna Gillespie; John F Cryan; Linda Giblin

doi:10.1007/978-3-319-16104-4_19

STC-1 Cells

Triona McCarthy, Brian D Green, Danielle Calderwood, Anna Gillespie, John F Cryan, Linda Giblin

School of Biological Sciences

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

11 Citations (Scopus)

3319 Downloads (Pure)

Abstract

Gastrointestinal hormones such as cholecystokinin (CCK), glucagon like peptide 1 (GLP-1), and peptide YY (PYY) play an important role in suppressing hunger and controlling food intake. These satiety hormones are secreted from enteroendocrine cells present throughout the intestinal tract. The intestinal secretin tumor cell line (STC-1) possesses many features of native intestinal enteroendocrine cells. As such, STC-1 cells are routinely used in screening platforms to identify foods or compounds that modulate secretion of gastrointestinal hormones in vitro. This chapter describes this intestinal cell model focussing on it’s applications, advantages and limitations. A general protocol is provided for challenging STC-1 cells with test compounds.

Original language	English
Title of host publication	The Impact of Food Bioactives on Health: in vitro and ex vivo models
Editors	Kitty Verhoeckx, Paul Cotter, Iván López-Expósito, Charlotte Kleiveland, Tor Lea, Alan Mackie, Teresa Requena, Dominika Swiatecka, Harry Wichers
Publisher	Springer
Pages	211-220
Number of pages	20
Volume	Part IV
ISBN (Electronic)	9783319161044
ISBN (Print)	9783319157917
DOIs	https://doi.org/10.1007/978-3-319-16104-4_19
Publication status	Published - 2015

Access to Document

10.1007/978-3-319-16104-4_19

STC-1 Cells
© The Author(s) 2015 The book is published with open access at SpringerLink.com Open Access This book is distributed under the terms of the Creative Commons Attribution Noncommercial License (https://creativecommons.org/licenses/by/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This book may be cited as: COST Action FA1005 “The Impact of Food Bio-Actives on Gut Health: In Vitro and Ex Vivo Models.”
Licence: CC BY-NC

http://download.springer.com/static/pdf/334/chp%253A10.1007%252F978-3-319-16104-4_19.pdf?originUrl=http%3A%2F%2Flink.springer.com%2Fchapter%2F10.1007%2F978-3-319-16104-4_19&token2=exp=1470136161~acl=%2Fstatic%2Fpdf%2F334%2Fchp%25253A10.1007%25252F978-3-319-16104-4_19.pdf%3ForiginUrl%3Dhttp%253A%252F%252Flink.springer.com%252Fchapter%252F10.1007%252F978-3-319-16104-4_19*~hmac=796a34fccc9bac313a4320f2117f837443ae13d81ce2b1fd4523f49c67373e17

Cite this

McCarthy, T., Green, B. D., Calderwood, D., Gillespie, A., Cryan, J. F., & Giblin, L. (2015). STC-1 Cells. In K. Verhoeckx, P. Cotter, I. López-Expósito, C. Kleiveland, T. Lea, A. Mackie, T. Requena, D. Swiatecka, & H. Wichers (Eds.), The Impact of Food Bioactives on Health: in vitro and ex vivo models (Vol. Part IV, pp. 211-220). Springer. https://doi.org/10.1007/978-3-319-16104-4_19

@inbook{a117686340374557928d77812776c93c,

title = "STC-1 Cells",

abstract = "Gastrointestinal hormones such as cholecystokinin (CCK), glucagon like peptide 1 (GLP-1), and peptide YY (PYY) play an important role in suppressing hunger and controlling food intake. These satiety hormones are secreted from enteroendocrine cells present throughout the intestinal tract. The intestinal secretin tumor cell line (STC-1) possesses many features of native intestinal enteroendocrine cells. As such, STC-1 cells are routinely used in screening platforms to identify foods or compounds that modulate secretion of gastrointestinal hormones in vitro. This chapter describes this intestinal cell model focussing on it{\textquoteright}s applications, advantages and limitations. A general protocol is provided for challenging STC-1 cells with test compounds.",

author = "Triona McCarthy and Green, {Brian D} and Danielle Calderwood and Anna Gillespie and Cryan, {John F} and Linda Giblin",

year = "2015",

doi = "10.1007/978-3-319-16104-4_19",

language = "English",

isbn = "9783319157917",

volume = "Part IV",

pages = "211--220",

editor = "Kitty Verhoeckx and Paul Cotter and L{\'o}pez-Exp{\'o}sito, {Iv{\'a}n } and Kleiveland, {Charlotte } and Tor Lea and Alan Mackie and Teresa Requena and Dominika Swiatecka and Harry Wichers",

booktitle = "The Impact of Food Bioactives on Health: in vitro and ex vivo models",

publisher = "Springer",

}

STC-1 Cells. / McCarthy, Triona; Green, Brian D; Calderwood, Danielle et al.
The Impact of Food Bioactives on Health: in vitro and ex vivo models. ed. / Kitty Verhoeckx; Paul Cotter; Iván López-Expósito; Charlotte Kleiveland; Tor Lea; Alan Mackie; Teresa Requena; Dominika Swiatecka; Harry Wichers. Vol. Part IV Springer, 2015. p. 211-220.

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

TY - CHAP

T1 - STC-1 Cells

AU - McCarthy, Triona

AU - Green, Brian D

AU - Calderwood, Danielle

AU - Gillespie, Anna

AU - Cryan, John F

AU - Giblin, Linda

PY - 2015

Y1 - 2015

N2 - Gastrointestinal hormones such as cholecystokinin (CCK), glucagon like peptide 1 (GLP-1), and peptide YY (PYY) play an important role in suppressing hunger and controlling food intake. These satiety hormones are secreted from enteroendocrine cells present throughout the intestinal tract. The intestinal secretin tumor cell line (STC-1) possesses many features of native intestinal enteroendocrine cells. As such, STC-1 cells are routinely used in screening platforms to identify foods or compounds that modulate secretion of gastrointestinal hormones in vitro. This chapter describes this intestinal cell model focussing on it’s applications, advantages and limitations. A general protocol is provided for challenging STC-1 cells with test compounds.

AB - Gastrointestinal hormones such as cholecystokinin (CCK), glucagon like peptide 1 (GLP-1), and peptide YY (PYY) play an important role in suppressing hunger and controlling food intake. These satiety hormones are secreted from enteroendocrine cells present throughout the intestinal tract. The intestinal secretin tumor cell line (STC-1) possesses many features of native intestinal enteroendocrine cells. As such, STC-1 cells are routinely used in screening platforms to identify foods or compounds that modulate secretion of gastrointestinal hormones in vitro. This chapter describes this intestinal cell model focussing on it’s applications, advantages and limitations. A general protocol is provided for challenging STC-1 cells with test compounds.

U2 - 10.1007/978-3-319-16104-4_19

DO - 10.1007/978-3-319-16104-4_19

M3 - Chapter (peer-reviewed)

SN - 9783319157917

VL - Part IV

SP - 211

EP - 220

BT - The Impact of Food Bioactives on Health: in vitro and ex vivo models

A2 - Verhoeckx, Kitty

A2 - Cotter, Paul

A2 - López-Expósito, Iván

A2 - Kleiveland, Charlotte

A2 - Lea, Tor

A2 - Mackie, Alan

A2 - Requena, Teresa

A2 - Swiatecka, Dominika

A2 - Wichers, Harry

PB - Springer

ER -

STC-1 Cells

Abstract

Access to Document

Fingerprint

Cite this