Steered Molecular Dynamic Simulations Reveal Critical Residues for (Un) Binding of Substrates, Inhibitors and a Product of the Malarial PFM1AAP

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Abstract

Malaria is one of the most prevalent and fatal infectious diseases of the world and is
compounded by wide spread drug resistance, with some strains developing resistance to current front-line anti-malarials. Plasmodium falciparum M1 alanyl aminopeptidase (PFM1AAP) is involved in the terminal stages of haemoglobin degradation and the generation of an amino acid pool to support parasitic growth and development. This represents a promising new anti-malarial target where inhibition of this enzyme is lethal to
Original languageEnglish
Pages (from-to)354a
Number of pages1
JournalBiophysical Journal
Volume112
Issue number3 (Supplement 1)
DOIs
Publication statusPublished - 03 Feb 2017

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