Stem cells applications in bone and tooth repair and regeneration: New insights, tools, and hopes

Eiman Abdel Meguid, Yuehai Ke, Junfeng Ji, Ahmed Hk El-Hashash

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)
528 Downloads (Pure)

Abstract

The exploration of stem and progenitor cells holds promise for advancing our understanding of the biology of tissue repair and regeneration mechanisms after injury. This will also help in the future use of stem cell therapy for the development of regenerative medicine approaches for the treatment of different tissue-specie defects or disorders such as bone, cartilages and tooth defects or disorders. Bone is a specialized connective tissue, with mineralized extracellular components that provide bones with both strength and rigidity, and thus enable bones to function in body mechanical supports and necessary locomotion process. New insights have been added to the use of different types of stem cells in bone and tooth defects over the last few years. In this concise review, we briefly describe bone structure as well as summarize recent research progress and accumulated information regarding the osteogenic differentiation of stem cells, as well as stem cell contributions to bone repair/regeneration, bone defects or disorders and both restoration and regeneration of bones and cartilages. We also discuss advances in the osteogenic differentiation and bone regeneration of dental and periodontal stem cells as well as in stem cell contributions to dentine regeneration and tooth engineering. 

Original languageEnglish
Pages (from-to)1825-1835
JournalJournal of Cellular Physiology
Volume233
Issue number3
Early online date23 May 2017
DOIs
Publication statusPublished - 30 Mar 2018

Keywords

  • Journal Article

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