Stereological estimation of Weibel-Palade bodies in the retinal vasculature of normal and diabetic dogs

H R Anderson, A W Stitt, T A Gardiner, D B Archer

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The absolute volume of Weibel-Palade (WP) bodies, the storage organelles of von Willebrand factor (vWF), was estimated by a stereological method in a known volume of central retina from normal and 5-year diabetic dogs. The results showed that the volume of WP bodies present in the endothelium of the retinal vasculature varies with blood vessel type and in diabetes. In both diabetic and normal dogs the endothelium of the retinal veins contained a higher volume of WP bodies than that of the retinal arteries. In dogs which had been diabetic for a duration of 5 years the volume of WP bodies present in the endothelium of retinal veins was significantly greater than in the endothelium of veins from the control animals. However, there was no significant difference in the volume of WP bodies present in the endothelium of retinal arteries or capillaries between the two groups of animals.

Original languageEnglish
Pages (from-to)705-10
Number of pages6
JournalCurrent eye research
Volume13
Issue number9
Publication statusPublished - Sep 1994

Bibliographical note

LR: 20061115; JID: 8104312; 0 (von Willebrand Factor); ppublish

Keywords

  • Animals
  • Cell Size
  • Diabetes Mellitus, Experimental/metabolism/pathology
  • Diabetic Retinopathy/metabolism/pathology
  • Dogs
  • Endothelium, Vascular/metabolism/ultrastructure
  • Male
  • Organelles/metabolism/ultrastructure
  • Retinal Artery/metabolism/ultrastructure
  • Retinal Vein/metabolism/ultrastructure
  • von Willebrand Factor/metabolism

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