Abstract
Direct and indirect evidence, Of unexpected stereoselective reductase-catalysed deoxygenations of sulfoxides, was found. The deoxygenations proceeded simultaneously, with the expected dioxygenase-catalysed asymmetric sulfoxidation of sulfides, during some biotransformations with the aerobic bacterium Pseudomonas putida UV4. Stereoselective reductase-catalysed asymmetric deoxygenation of racemic alkylaryl, dialkyl and phenolic sulfoxides was observed, without evidence of the reverse sulfoxidation reaction, using anaerobic bacterial strains. A purified dimethyl sulfoxide reductase, obtained from the intact cells of the anaerobic bacterium Citrobacter braakii DMSO 11, yielded, from the corresponding racemates, enantiopure alkylaryl sulfoxide and thiosulfinate samples.
Original language | English |
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Pages (from-to) | 554-561 |
Number of pages | 8 |
Journal | Organic and Biomolecular Chemistry |
Volume | 2 |
Issue number | 4 |
DOIs | |
Publication status | Published - 21 Feb 2004 |
ASJC Scopus subject areas
- General Biochemistry,Genetics and Molecular Biology
- General Chemistry