Strategies for the controlled hydrostannylation of alkynes

Dean D. Roberts; Mark G. McLaughlin

doi:10.1002/ejoc.202300755

Strategies for the controlled hydrostannylation of alkynes

Dean D. Roberts
, Mark G. McLaughlin^*

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Research output: Contribution to journal › Review article › peer-review

4 Citations (Scopus)

186 Downloads (Pure)

Abstract

Organostannanes have represented one of the most widely applied reagents in modern cross-coupling chemistry and represent a key reagent in the synthesis of a range of pharmaceutically relevant scaffolds. This Concept article summarizes recent advances in approaches to the synthesis of these building blocks in a stereocontrolled and regiocontrolled manner. Particular focus is paid to methods which allow for divergent synthesis of alkenylstannanes and developments in methods which present opportunities for sustainable synthesis.

Original language	English
Article number	e202300755
Number of pages	6
Journal	European Journal of Organic Chemistry
Volume	26
Issue number	42
Early online date	27 Sept 2023
DOIs	https://doi.org/10.1002/ejoc.202300755
Publication status	Published - Nov 2023

Keywords

Organic Chemistry
Physical and Theoretical Chemistry
synthesis
hydrometalation
organostannane
catalysis
regioselective

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10.1002/ejoc.202300755Licence: CC BY

Strategies for the controlled hydrostannylation of alkynes
Copyright 2023 The Authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 4.79 MBLicence: CC BY

Cite this

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title = "Strategies for the controlled hydrostannylation of alkynes",

abstract = "Organostannanes have represented one of the most widely applied reagents in modern cross-coupling chemistry and represent a key reagent in the synthesis of a range of pharmaceutically relevant scaffolds. This Concept article summarizes recent advances in approaches to the synthesis of these building blocks in a stereocontrolled and regiocontrolled manner. Particular focus is paid to methods which allow for divergent synthesis of alkenylstannanes and developments in methods which present opportunities for sustainable synthesis. ",

keywords = "Organic Chemistry, Physical and Theoretical Chemistry, synthesis, hydrometalation, organostannane, catalysis, regioselective",

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AU - Roberts, Dean D.

AU - McLaughlin, Mark G.

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N2 - Organostannanes have represented one of the most widely applied reagents in modern cross-coupling chemistry and represent a key reagent in the synthesis of a range of pharmaceutically relevant scaffolds. This Concept article summarizes recent advances in approaches to the synthesis of these building blocks in a stereocontrolled and regiocontrolled manner. Particular focus is paid to methods which allow for divergent synthesis of alkenylstannanes and developments in methods which present opportunities for sustainable synthesis.

AB - Organostannanes have represented one of the most widely applied reagents in modern cross-coupling chemistry and represent a key reagent in the synthesis of a range of pharmaceutically relevant scaffolds. This Concept article summarizes recent advances in approaches to the synthesis of these building blocks in a stereocontrolled and regiocontrolled manner. Particular focus is paid to methods which allow for divergent synthesis of alkenylstannanes and developments in methods which present opportunities for sustainable synthesis.

KW - Organic Chemistry

KW - Physical and Theoretical Chemistry

KW - synthesis

KW - hydrometalation

KW - organostannane

KW - catalysis

KW - regioselective

U2 - 10.1002/ejoc.202300755

DO - 10.1002/ejoc.202300755

M3 - Review article

SN - 1434-193X

VL - 26

JO - European Journal of Organic Chemistry

JF - European Journal of Organic Chemistry

IS - 42

M1 - e202300755

ER -

Strategies for the controlled hydrostannylation of alkynes

Abstract

Keywords

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