Abstract
Dissolving microarray patches (DMAP) contain micron-scale projections and are usually made from biocompatible water-soluble polymers containing a high amount of drug in their tips, to be delivered through the skin layers. The challenge regarding DMAP is the detachment of the tips from the baseplate. & nbsp; This impacts the wearing time, the delivery efficiency of the skin, and patient compliance. In our previous work, we reported the delivery of cabotegravir sodium (CAB Na), an anti-HIV drug, necessitting the wearing time of more than 1 hour [1].Herein we developed strategies to reduce the wearing time of DMAP containing cabotegravir sodium from hours to 10 minutes by facilitating tip detachment from the baseplate.
| Original language | English |
|---|---|
| Article number | 1083 |
| Journal | British Journal of Pharmacy |
| Volume | 7 |
| Issue number | 2 |
| Early online date | 04 Nov 2022 |
| DOIs | |
| Publication status | Early online date - 04 Nov 2022 |
| Event | 13th APS PharmSci International Conference 2022 - Almac - Duration: 07 Sep 2022 → 09 Sep 2022 |
Keywords
- Management Science and Operations Research
- Mechanical Engineering
- Energy Engineering and Power Technology
Access to Document
- Strategies to reduce the wearing time of cabotegravir sodium dissolving microarray pacthes by facilitating fast tip detachment from the baseplate
Copyright 2022 the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.