Striking senescence with sodium transporter inhibition

Bettina Schock; Steven O'Reilly

doi:10.1016/j.molmed.2024.07.002

Striking senescence with sodium transporter inhibition

Research output: Contribution to journal › Article › peer-review

Abstract

Senescence is associated with multiple morbidities and therapeutic targeting of these cells is a key aim. In a recent study, Katsuumi et al. found that targeting sodium-glucose co-transporter 2 (SGLT2) promoted immune clearance of senescent cells via programmed cell death-1 ligand (PD-L1) suppression, thus promoting immunosurveillance. This could have profound implications for many age-related diseases, including cancer and frailty.

Original language	English
Journal	Trends in Molecular Medicine
Early online date	13 Jul 2024
DOIs	https://doi.org/10.1016/j.molmed.2024.07.002
Publication status	Early online date - 13 Jul 2024

Keywords

senolysis
age-related diseases
senescence
immunosurveillance
AMPK

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Striking senescence with sodium transporter inhibition",

abstract = "Senescence is associated with multiple morbidities and therapeutic targeting of these cells is a key aim. In a recent study, Katsuumi et al. found that targeting sodium-glucose co-transporter 2 (SGLT2) promoted immune clearance of senescent cells via programmed cell death-1 ligand (PD-L1) suppression, thus promoting immunosurveillance. This could have profound implications for many age-related diseases, including cancer and frailty. ",

keywords = "senolysis, age-related diseases, senescence, immunosurveillance, AMPK",

author = "Bettina Schock and Steven O'Reilly",

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language = "English",

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AU - Schock, Bettina

AU - O'Reilly, Steven

PY - 2024/7/13

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N2 - Senescence is associated with multiple morbidities and therapeutic targeting of these cells is a key aim. In a recent study, Katsuumi et al. found that targeting sodium-glucose co-transporter 2 (SGLT2) promoted immune clearance of senescent cells via programmed cell death-1 ligand (PD-L1) suppression, thus promoting immunosurveillance. This could have profound implications for many age-related diseases, including cancer and frailty.

AB - Senescence is associated with multiple morbidities and therapeutic targeting of these cells is a key aim. In a recent study, Katsuumi et al. found that targeting sodium-glucose co-transporter 2 (SGLT2) promoted immune clearance of senescent cells via programmed cell death-1 ligand (PD-L1) suppression, thus promoting immunosurveillance. This could have profound implications for many age-related diseases, including cancer and frailty.

KW - senolysis

KW - age-related diseases

KW - senescence

KW - immunosurveillance

KW - AMPK

U2 - 10.1016/j.molmed.2024.07.002

DO - 10.1016/j.molmed.2024.07.002

M3 - Article

C2 - 39004548

SN - 1471-499X

JO - Trends in Molecular Medicine

JF - Trends in Molecular Medicine

ER -

Striking senescence with sodium transporter inhibition

Abstract

Keywords

UN SDGs

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