STRING 8 - A global view on proteins and their functional interactions in 630 organisms

Lars J. Jensen, Michael Kuhn, Manuel Stark, Samuel Chaffron, Chris Creevey, Jean Muller, Tobias Doerks, Philippe Julien, Alexander Roth, Milan Simonovic, Peer Bork*, Christian von Mering

*Corresponding author for this work

Research output: Contribution to journalArticle

1631 Citations (Scopus)

Abstract

Functional partnerships between proteins are at the core of complex cellular phenotypes, and the networks formed by interacting proteins provide researchers with crucial scaffolds for modeling, data reduction and annotation. STRING is a database and web resource dedicated to protein-protein interactions, including both physical and functional interactions. It weights and integrates information from numerous sources, including experimental repositories, computational prediction methods and public text collections, thus acting as a meta-database that maps all interaction evidence onto a common set of genomes and proteins. The most important new developments in STRING 8 over previous releases include a URL-based programming interface, which can be used to query STRING from other resources, improved interaction prediction via genomic neighborhood in prokaryotes, and the inclusion of protein structures. Version 8.0 of STRING covers about 2.5 million proteins from 630 organisms, providing the most comprehensive view on protein-protein interactions currently available. STRING can be reached at http://string-db.org/.

Original languageEnglish
JournalNucleic Acids Research
Volume37
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 09 Jan 2009
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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    Jensen, L. J., Kuhn, M., Stark, M., Chaffron, S., Creevey, C., Muller, J., Doerks, T., Julien, P., Roth, A., Simonovic, M., Bork, P., & von Mering, C. (2009). STRING 8 - A global view on proteins and their functional interactions in 630 organisms. Nucleic Acids Research, 37(SUPPL. 1). https://doi.org/10.1093/nar/gkn760