Structural and functional changes over time in MacTel patients

Steffen Schmitz-Valckenberg, E E Lin Ong, Gary S Rubin, Tunde Peto, Adnan Tufail, Catherine A Egan, Alan C Bird, Fred W Fitzke

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32 Citations (Scopus)

Abstract

PURPOSE: To investigate functional and morphologic alterations over a 1-year review analysis in patients with type 2 idiopathic juxtafoveal retinal telangiectasia (MacTel).

METHODS: Nine eyes of 9 patients with MacTel underwent repeated scotopic and photopic fine matrix mapping (FMM), 10-2 photopic microperimetry, and imaging studies.

RESULTS: Early Treatment Diabetic Retinopathy Study visual acuity assessment showed a median difference between examinations of 1.0 letter (range, -3 to 4 letters). The difference of sensitivity values of all test points was 4.5 dB (range, 0.4 -5.5 dB) for microperimetry 1, 0.4 dB (range, -0.8 to 1.7 dB) for photopic, and -1.7 dB (range, -6.1 to 1.0 dB) for scotopic fine matrix mapping, respectively. The difference in test points of more than a 10-dB loss compared with age-matched controls was higher for scotopic than for photopic testing (P= 0.03, Wilcoxon signed ranks test). Small progression of scotoma correlated with a slight increase in retinal blood vessel dilatation and hyperfluorescence and subtle enlargement of pigmented plaques.

CONCLUSION: Changes in central visual acuity and microperimetry testing after 1 year most likely do not extend beyond test-retest variability. The deterioration of scotopic sensitivity confirms our previous results of more severe rod compared with cone dysfunction in MacTel. Changes in fine detail visual function over a 1-year period may be useful parameters for interventional trials.

Original languageEnglish
Pages (from-to)1314-20
Number of pages7
JournalRetina (Philadelphia, Pa.)
Volume29
Issue number9
DOIs
Publication statusPublished - Oct 2009

Keywords

  • Adult
  • Aged
  • Fluorescein Angiography
  • Humans
  • Middle Aged
  • Photoreceptor Cells, Vertebrate
  • Prospective Studies
  • Retinal Diseases
  • Retinal Vessels
  • Scotoma
  • Telangiectasis
  • Tomography, Optical Coherence
  • Visual Acuity
  • Visual Field Tests
  • Visual Fields
  • Journal Article
  • Research Support, Non-U.S. Gov't

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  • Cite this

    Schmitz-Valckenberg, S., Ong, E. E. L., Rubin, G. S., Peto, T., Tufail, A., Egan, C. A., Bird, A. C., & Fitzke, F. W. (2009). Structural and functional changes over time in MacTel patients. Retina (Philadelphia, Pa.), 29(9), 1314-20. https://doi.org/10.1097/IAE.0b013e3181a4d2f1