Structural basis for understanding structure-activity relationships for the glutamate binding site of the NMDA receptor

I.G. Tikhonova, I.I. Baskin, V.A. Palyulin, N.S. Zefirov, S.O. Bachurin

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

We present new homology-based models of the glutamate binding site (in closed and open forms) of the NMDA receptor NR2B subunit derived from X-ray structures of the water soluble AMPA sensitive glutamate receptor. The models were used for revealing binding modes of agonists and competitive antagonists, as well as for rationalizing known experimental facts concerning structure-activity relationships: (i) the switching between the agonist and the antagonist modes of action upon lengthening the chain between the distal acidic group and the amino acid moiety, (ii) the preference for the methyl group attached to the a-amino group of ligands, (iii) the preference for the D-configuration of agonists and antagonists, and (iv) the existence of "superacidic" agonists.
Original languageEnglish
Pages (from-to)3836-3843
Number of pages8
JournalJournal of Medicinal Chemistry
Volume45
Issue number18
DOIs
Publication statusPublished - 29 Aug 2002

ASJC Scopus subject areas

  • Organic Chemistry

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